CMV infection affects the phenotype but not the lifespan of T-cells in humans.

Both CD4+ and CD8+ T-cells in CMV-infected individuals upregulate the expression of senescence markers (e.g. CD57, KLRG-1) and downregulate the expression of co-stimulatory and proliferation markers (e.g. CD28, Ki-67). By separately analyzing th...

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Bibliographic Details
Main Author:	Sara P. H. van den Berg (8703927) (author)
Other Authors:	Lyanne Y. Derksen (11846999) (author), Julia Drylewicz (567694) (author), Nening M. Nanlohy (10748466) (author), Lisa Beckers (11847002) (author), Josien Lanfermeijer (10724013) (author), Stephanie N. Gessel (11847005) (author), Martijn Vos (10724019) (author), Sigrid A. Otto (11847008) (author), Rob J. de Boer (7330310) (author), Kiki Tesselaar (651248) (author), José A. M. Borghans (10724022) (author), Debbie van Baarle (164622) (author)
Published:	2021
Subjects:	Biochemistry Cell Biology Molecular Biology Ecology Immunology Developmental Biology Cancer Infectious Diseases Computational Biology Biological Sciences not elsewhere classified sup >+</ sup remains unclear whether healthy older adults stage differentiation markers div >< p cmv could simply humans </ p cell populations using bulk memory cd8 latent cytomegalovirus infection specific memory cd8 cell populations vivo </ apoptosis markers specific cd8 memory cd4 cell pool work suggests versus cmv phenotypical differences major impact immune system gradual accumulation differ significantly deuterium labelling decreased ki cmv specific cmv infection circulating cmv
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CMV infection affects the phenotype but not the lifespan of T-cells in humans.

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