RORγ enhances IAV replication by enhancing cholesterol biosynthesis.

RORγ enhances IAV replication by enhancing cholesterol biosynthesis.

<p>(A) The monolayers of NL20 cells seeded on coverslips were pre-incubated in the absence of presence of XY018 (2 μM) or cholesterol (5 μg/ml) for 4 h and then infected with H5N1 (SY) (1 MOI) or H1N1 (PR8) (5 MOI) virus. After incubation in serum-free media for 16 h, cells were stained for ch...

Full description

Saved in:
Bibliographic Details
Main Author: Jingting Zhang (791900) (author)
Other Authors: Ruixuan Cao (22493337) (author), Yujie Wang (308942) (author), Yuling Sun (5688665) (author), Xiaoyue Ji (14272545) (author), Penggang Liu (2512177) (author), Kaituo Liu (10512226) (author), Jing Sun (141206) (author), Xiaojun Chen (317104) (author), Demin Cai (621171) (author), Pinghu Zhang (4029842) (author), Xiaoquan Wang (305826) (author), Xiufan Liu (26081) (author), Xiulong Xu (342383) (author)
Published: 2025
Subjects:
Biochemistry
Microbiology
Cell Biology
Genetics
Molecular Biology
Immunology
Cancer
Science Policy
Mental Health
Infectious Diseases
Plant Biology
Virology
xlink "> infection
turn activate ap1
supply substantial amounts
sterol regulatory element
orphan nuclear receptor
ror &# 947
facilitate &# 160
nf -&# 954
exogenous cholesterol rescues
iav infection induces
axis </ p
induced hmgcr expression
xy018 treatment reduces
facilitate virus replication
&# 954
hmgcr ),
cholesterol biosynthesis
cellular cholesterol
viral replication
terminal kinase
suppress iav
retinoic acid
prolongs survival
methylglutaryl coenzyme
key enzyme
jun n
inhibitory effect
infected mice
ikk ),
downstream kinases
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items