Neutrophil depletion impairs F. monophora clearance in footpads of infected mice.

(A) Representative images of F. monophora colonies grown from footpad tissue homogenates on PDA for 10 days. Df: dilution factor. (B) The fungal burden of footpads presented by CFU was significantly increased in the PMNs-depletion group when compared with the isotype grou...

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Bibliographic Details
Main Author:	Huan Huang (724980) (author)
Other Authors:	Minying Li (4477666) (author), Yinghui Liu (322347) (author), Yangxia Chen (12104345) (author), Zhenmou Xie (12104348) (author), Mingfen Luo (12867757) (author), Dongmei Li (176178) (author), Hongfang Liu (39593) (author), Liyan Xi (312918) (author)
Published:	2025
Subjects:	Microbiology Cell Biology Physiology Ecology Immunology Infectious Diseases Biological Sciences not elsewhere classified potential therapeutic implications murine footpad model low cure rate infected footpad tissues high recurrence rate prolonged treatment duration play complex roles mediate immune responses impaired fungal clearance early fungal clearance depleted mouse model isotype control mice div >< p neutrophil extracellular traps fonsecaea monophora </ chromoblastomycosis </ p monophora </ depleted mice vitro </ prolonged inflammation mediated responses fungal infections fungal burden mice led neutrophils play targeting neutrophil study investigated neutrophil depletion morphological transition like cells key role inflammatory cytokines host defense histopathological changes findings underscore findings demonstrated especially macrophages elevated levels cytokine profiles culture conditions critical role cbm ), black fungi also associated
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Neutrophil depletion impairs <i>F. monophora</i> clearance in footpads of infected mice.

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