Discovery of THB Derivates as Ferroptosis Inhibitors for the Treatment of Acute Kidney Injury by Targeting VDAC

Discovery of THB Derivates as Ferroptosis Inhibitors for the Treatment of Acute Kidney Injury by Targeting VDAC

Acute kidney injury (AKI), a clinical syndrome marked by high morbidity and mortality, remains a significant challenge due to the lack of effective therapeutic options. The accumulation of Fe<sup>2+</sup> and reactive oxygen species (ROS) in injured renal cells, which triggers ferroptosi...

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Bibliographic Details
Main Author: Shengkuan Peng (21409265) (author)
Other Authors: Wenhao Zhang (303192) (author), Qiaoyi Sun (21409268) (author), Wenqiang Zhang (470965) (author), Yadong Chen (621664) (author), Zhicheng Lv (13872500) (author), Zhihang Fang (19866069) (author), Xian Wei (4326325) (author), Tao Lu (39406) (author), Guo Chen (182090) (author), Yu Jiao (817904) (author)
Published: 2025
Subjects:
Biochemistry
Medicine
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Sociology
Marine Biology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
vivo experiments confirmed
significant challenge due
reactive oxygen species
injured renal cells
effective therapeutic options
dependent anion channel
clinical syndrome marked
acute kidney injury
significantly reduced ros
34a </ b
2 +</ sup
novel ferroptosis inhibitors
amino thb derivatives
thb derivatives
ferroptosis inhibitors
triggers ferroptosis
thb derivates
thb ),
ferroptosis inhibitor
vdac ).
structural optimization
results highlight
restored glutathione
natural product
key driver
high morbidity
20 nm
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