Characterization of the wtAAV2-induced alterations to the human replisome using iPOND-MS.

<p><b>(A)</b> Venn diagram depicting the number of detected proteins enriched in 293T cells (red), U2OS cells (blue) and shared between the two cell types (yellow). (B) Scatter plot comparing the mean log2 abundance ratios between wtAAV2 infected and uninfected cells among the 822...

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Detalhes bibliográficos
Autor principal:	Monnette F. Summers (22075935) (author)
Outros Autores:	MegAnn K. Haubold (15990697) (author), Marcel Morgenstern (5679425) (author), Phoenix Shepherd (22075938) (author), Clairine I. S. Larsen (15990709) (author), Ava E. Bartz (22075941) (author), Gopishankar Thirumoorthy (11224754) (author), Robert N. Kirchdoerfer (2418154) (author), Joshua J. Coon (388014) (author), Kavi P. M. Mehta (22075944) (author), Kinjal Majumder (9530459) (author)
Publicado em:	2025
Assuntos:	Biophysics Biochemistry Microbiology Cell Biology Genetics Molecular Biology Cancer Science Policy Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified therapeutic transgene delivery rna processing machinery mediated knockdown leads increasing rep 68 dna repair factors derived oncolytic agents brdu analogs followed replication stress proteins induced replication stress 78 gene expression supports virus replication induce replication stress competent wtaav2 leads associated virus 2 cellular replication forks stranded dna viruses div >< p host replication forks cell replication stress rpa rescues wtaav2 raav2 infected cells associated virus induce host host cells ectopic expression rpa molecules rpa activity cellular stores cellular replisomes host genome host chromosome wtaav2 genome replicative wtaav2 pulsed wtaav2 taken together rodent parvovirus replicative wild raav2 genomes proteomic analysis parvoviridae </ molecule imaging findings suggest family induces empty capsids elevated levels dependent manner chemical inhibition
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Characterization of the wtAAV2-induced alterations to the human replisome using iPOND-MS.

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