Perturbation on the kinase activity of CaMKII affects sleep duration.

(A) Schematic diagram of CaMKIIβ activation via deletion of its C-terminus. Deletion of the regulatory segment and linker region exposes the kinase domain of the CaMKIIβ and makes the enzyme constitutively activated. (B, C) Sleep/wake parameters <b&g...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Daisuke Tone (9458617) (author)
مؤلفون آخرون:	Koji L. Ode (9073473) (author), Qianhui Zhang (2091760) (author), Hiroshi Fujishima (3027426) (author), Rikuhiro G. Yamada (13905793) (author), Yoshiki Nagashima (5853146) (author), Katsuhiko Matsumoto (539704) (author), Zhiqing Wen (13905796) (author), Shota Y. Yoshida (13905799) (author), Tomoki T. Mitani (13905802) (author), Yuki Arisato (13905805) (author), Rei-ichiro Ohno (13905808) (author), Maki Ukai-Tadenuma (13905811) (author), Junko Yoshida Garçon (13905814) (author), Mari Kaneko (13905817) (author), Shoi Shi (176534) (author), Hideki Ukai (5770679) (author), Kazunari Miyamichi (175811) (author), Takashi Okada (162457) (author), Kenta Sumiyama (142842) (author), Hiroshi Kiyonari (106447) (author), Hiroki R. Ueda (27980) (author)
منشور في:	2022
الموضوعات:	Biochemistry Cell Biology Genetics Molecular Biology Neuroscience Physiology Cancer Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified “ phosphorylation hypothesis phosphorylation states suppress distinct phosphorylation states sleep regulation depends decrease sleep duration core sleep regulator div >< p phosphorylation state promotes knockout mice revealed camkiiβ mutant mimicking sleep </ p phosphorylation states sleep state camk2b </ sleep ” awake state underlying mechanism results suggest promoting kinase leading us largely unknown kinase activity almost 2
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Perturbation on the kinase activity of CaMKII affects sleep duration.

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