Augmented erythrophagocytosis in LD-R-infected-MФs at 24 hrs pi in concomitance with SIRP α degradation.

<p><b>(A.i.)</b> Confocal images show no significant erythrophagocytosed RBCs in both LD-S and LD-R infected-MФs at 4 hrs pi. DAPI stains nucleus, LD were labeled with GFP (green), and RBCs were labeled with Cyto-Red dye after infection to check engulfed RBCs in LD-infected-MФs. &l...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Souradeepa Ghosh (14276657) (author)
مؤلفون آخرون:	Krishna Vamshi Chigicherla (20649145) (author), Shirin Dasgupta (20649148) (author), Yasuyuki Goto (22965) (author), Budhaditya Mukherjee (106862) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Microbiology Cell Biology Biotechnology Evolutionary Biology Ecology Inorganic Chemistry Hematology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified unresponsiveness points towards treating visceral leishmaniasis sustaining heightened levels selectively reshuffling macrophage recent clinical isolates leishmania donovani </ inherent metabolic shift even though anti div >< p surface iron exporter subsequent iron insufficiency higher iron utilization triggering oxidative outburst gained increased potential withstand elevated ros elevated ros levels pv thereby gaining pentavalent antimonials relies surplus iron iron within oxidative stress increased erythrophagocytosis two proteases survival edge surprising strategy study highlights sensitive counterparts parasitophorous vacuoles leishmanial activity intracellular pathogens infected macrophages genetic adaptation evolutionary persistence complex interplay cd47 surveillance aggressive proliferation
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Augmented erythrophagocytosis in LD-R-infected-MФs at 24 hrs pi in concomitance with SIRP α degradation.

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