γ‑Secretase Cleaves Bifunctional Fatty Acid-Conjugated Small Molecules with Amide Bonds in Mammalian Cells

γ‑Secretase Cleaves Bifunctional Fatty Acid-Conjugated Small Molecules with Amide Bonds in Mammalian Cells

Connecting two small molecules, such as ligands, fluorophores, or lipids, together via a linker with amide bonds is a widely used strategy to generate synthetic bifunctional molecules for various biological and biomedical applications. Such bifunctional molecules have been used in live-cell experime...

Full description

Saved in:
Bibliographic Details
Main Author: Kai Tahara (9245264) (author)
Other Authors: Akinobu Nakamura (414876) (author), Xiaotong Wang (276499) (author), Keishi Mitamura (20299691) (author), Yuki Ichihashi (3775042) (author), Keiko Kano (493477) (author), Emi Mishiro-Sato (14426149) (author), Kazuhiro Aoki (56255) (author), Yasuteru Urano (656510) (author), Toru Komatsu (1521958) (author), Shinya Tsukiji (1919149) (author)
Published: 2024
Subjects:
Biophysics
Biochemistry
Cell Biology
Genetics
Molecular Biology
Neuroscience
Pharmacology
Biotechnology
Immunology
Cancer
Hematology
Chemical Sciences not elsewhere classified
several different types
previously overlooked consideration
molecule ligand trimethoprim
chemical biology research
targeting bifunctional molecule
linked bifunctional compounds
based bifunctional molecules
two small molecules
conjugated small molecules
widely used strategy
undergo intracellular degradation
lack lipid modification
first identified γ
bifunctional molecules
intracellular degradation
various biological
together via
next investigated
n </
hydrophobic groups
findings highlight
cell experiments
bond cleavage
biomedical applications
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items