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<div><p>Polycomb Repressive Complexes (PRCs) are known for chemically modifying histones to compact chromatin structure and repress transcription. Broadly speaking, PRC1 monoubiquitinates histone 2A at lysine 119 (H2AK119ub), and PRC2 methylates histone H3 lysine 27 (H3K27me3, H3K27me2 a...

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Detalhes bibliográficos
Autor principal:	Aditya Parmar (22331873) (author)
Outros Autores:	Anjali Srinivasan (22331876) (author), Lena Krockenberger (22331879) (author), Abijith Augustine (22331882) (author), Owin Gong (22331885) (author), Addison C. Bullard (22331888) (author), Riya Kalra (22331891) (author), Leya Ledvin (22331894) (author), Dylan Pilz (21246648) (author), Jonathan Tawil (22331897) (author), Challana E. Tea (22331900) (author), Kelly C. Wang (22331903) (author), Olivia Urso (22331906) (author), Larissa M. Kaube (22331909) (author), Ying Sun (23237) (author), Roman Sasik (193092) (author), Kyle J. Gaulton (7703387) (author), Kathleen M. Fisch (4730523) (author), Cole J. Ferguson (22331912) (author)
Publicado em:	2025
Assuntos:	Biochemistry Cell Biology Genetics Molecular Biology Neuroscience Developmental Biology Cancer Science Policy two postnatal timepoints two marks colocalized heterochromatic zones dominated expressed gene bodies dependent histone modifications data lead us chemically modifying histones 3 months ). dynamic chromatin state compact chromatin structure regulatory elements tended prc2 product h3k27me3 dynamically regulate euchromatin normal prc activities h2ak119ub appears within promoters reduced transcription associated modifications h3k4me3 regulatory elements chromatin signature map prc h2ak119ub within used cut repress transcription remaining uncorrelated neurodevelopmental disorders mouse cerebellum lysine 119 h2ak119ub ), epigenetic dysregulation day 12 corresponding mrnas cerebellum matures cerebellum compared broadly speaking also gain 2 independently
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