Antimycobacterial Muraymycins Isolated from Streptomyces sp. NRRL 30475 Using OSMAC and Precursor-Feeding Strategies

Three mutant strains of Streptomyces sp. NRRL 30471 were screened with eight different media based on “One Strain Many Compounds” (OSMAC) and precursor-feeding strategies. Five new muraymycins, D5–D9 (4–8), together with three known congeners...

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المؤلف الرئيسي:	Fengjuan Zhou (2293168) (author)
مؤلفون آخرون:	Jiawen Sun (8596362) (author), Rui Zhang (13940) (author), Hanyang Peng (21518906) (author), Yunyao Ren (21518909) (author), Youjuan Zhu (8306472) (author), Yongdi Sun (21518912) (author), Steven G. Van Lanen (7511822) (author), Wei Chen (23863) (author), Xiachang Wang (534538) (author)
منشور في:	2025
الموضوعات:	Biochemistry Microbiology Molecular Biology Ecology Infectious Diseases Environmental Sciences not elsewhere classified three known congeners positive control isoniazid nmr spectroscopic data isopropyl hydantoin structure first natural muraymycin elucidated using hr 3 ′- oh mycolicibacterium smegmatis </ nrrl 30475 using d5 (< b five new muraymycins 6 </ b 4 </ b antimycobacterial muraymycins isolated muraymycins d1 tuberculosis </ streptomyces </ nrrl 30471 new compounds antimycobacterial effects unique dehydrocyclization ribofuranoside moiety peptide moiety l ). feeding strategies even better epicapreomycidine imide antituberculosis antibiotics 5 g 16 μg
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Antimycobacterial Muraymycins Isolated from <i>Streptomyces</i> sp. NRRL 30475 Using OSMAC and Precursor-Feeding Strategies

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