CYP46A1 and 24-OHC are up-regulated in PD patients and PD model mice.

CYP46A1 and 24-OHC are up-regulated in PD patients and PD model mice.

<p><b> (A)</b> Immunohistochemistry showing the levels of CYP46A1 in the SNpc of PD patients (<i>n</i> = 5 subjects in each group). Scale bar, 20 μm. <b>(B)</b> Levels of 24-OHC in the plasma of PD patients (<i>n</i> = 38) and control subjects (&...

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Main Author: Lijun Dai (2407099) (author)
Other Authors: Jiannan Wang (154792) (author), Lanxia Meng (564023) (author), Xingyu Zhang (408987) (author), Tingting Xiao (838381) (author), Min Deng (114029) (author), Guiqin Chen (5955809) (author), Jing Xiong (218613) (author), Wei Ke (158476) (author), Zhengyuan Hong (20746042) (author), Lihong Bu (443666) (author), Zhentao Zhang (218622) (author)
Published: 2025
Subjects:
Biochemistry
Cell Biology
Neuroscience
Science Policy
Biological Sciences not elsewhere classified
whereas genetic removal
parkinson &# 8217
mitochondrial dysfunction induced
activation gene 3
nigrostriatal dopaminergic degeneration
neurodegenerative disease characterized
xbp1 &# 8211
ohc promote neurotoxicity
disease </ p
dopaminergic neurons
substantia nigra
strategies aimed
specific oxysterol
ohc exacerbates
ohc enhances
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mouse model
modifying therapies
lewy bodies
intracerebral injection
cerebrospinal fluid
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