Mechanism of wtAAV2-induced RPA exhaustion that leads to replication stress on the host genome.

<p>wtAAV2 infection depletes the host genome of RPA molecules, rendering the host replisomes vulnerable to replication stress (middle panel). At high MOI’s of wtAAV2 infection, this RPA exhaustion leads to induction of cellular DNA damage (right panel) while restricting viral gene expression....

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書誌詳細
第一著者:	Monnette F. Summers (22075935) (author)
その他の著者:	MegAnn K. Haubold (15990697) (author), Marcel Morgenstern (5679425) (author), Phoenix Shepherd (22075938) (author), Clairine I. S. Larsen (15990709) (author), Ava E. Bartz (22075941) (author), Gopishankar Thirumoorthy (11224754) (author), Robert N. Kirchdoerfer (2418154) (author), Joshua J. Coon (388014) (author), Kavi P. M. Mehta (22075944) (author), Kinjal Majumder (9530459) (author)
出版事項:	2025
主題:	Biophysics Biochemistry Microbiology Cell Biology Genetics Molecular Biology Cancer Science Policy Mental Health Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified therapeutic transgene delivery rna processing machinery mediated knockdown leads increasing rep 68 dna repair factors derived oncolytic agents brdu analogs followed replication stress proteins induced replication stress 78 gene expression supports virus replication induce replication stress competent wtaav2 leads associated virus 2 cellular replication forks stranded dna viruses div >< p host replication forks cell replication stress rpa rescues wtaav2 raav2 infected cells associated virus induce host host cells ectopic expression rpa molecules rpa activity cellular stores cellular replisomes host genome host chromosome wtaav2 genome replicative wtaav2 pulsed wtaav2 taken together rodent parvovirus replicative wild raav2 genomes proteomic analysis parvoviridae </ molecule imaging findings suggest family induces empty capsids elevated levels dependent manner chemical inhibition
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Mechanism of wtAAV2-induced RPA exhaustion that leads to replication stress on the host genome.

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