Locked Nucleic Acid-Modified Force Probe Reveals High-Force Regulation of Yes-Associated Protein through Talin–Vinculin in Breast Cancer

Integrins facilitate cellular mechanotransduction by transmitting mechanical cues from the extracellular matrix. While various DNA-based force probes have demonstrated integrin tension-dependent cellular responses, these typically measure forces up to ∼56 pN, limiting investigations of higher-force...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Tram Thi Hong Le (22368056) (author)
مؤلفون آخرون:	Jaehun Jung (600064) (author), Linh Thanh Nguyen (22368059) (author), Min Ju Shon (2048425) (author), Byoung Choul Kim (1965961) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Medicine Cell Biology Molecular Biology Physiology Biotechnology Developmental Biology Cancer Computational Biology Biological Sciences not elsewhere classified ∼ 56 pn typically measure forces transmitting mechanical cues locked nucleic acid increased stability compared dependent cellular responses actin fiber disruption diminished mechanical signaling force mechanobiological responses demonstrated integrin tension based force probes talin – vinculin integrin tension nuclear signaling based sensors force regulation force mechanotransduction force conditions various dna traditional dna tgts provide robust platform nuclear translocation marked reduction limiting investigations focal adhesions findings suggest fas ), fa disassembly extracellular matrix elevated tensions effect correlates cytoskeletal dynamics biphasic interaction associated protein
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Locked Nucleic Acid-Modified Force Probe Reveals High-Force Regulation of Yes-Associated Protein through Talin–Vinculin in Breast Cancer

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