Cohort CAT: FluoroSpot IFN-γ and GzB responses for non-protected participant v33 (HLA A23:01 (A24)/A33:03 (A03), B51:01 (B07)/B58:01 (B58) to AMA1 Ap4, Ap8 and Ap10 peptide pools, 15mer peptides, and synthesized predicted epitopes.

<p>Cohort CAT: FluoroSpot IFN-γ and GzB responses for non-protected participant v33 <u>(</u>HLA A*23:01 (A24)/A*33:03 (A03), B*51:01 (B07)/B*58:01 (B58) to AMA1 Ap4, Ap8 and Ap10 peptide pools, 15mer peptides, and synthesized predicted epitopes.</p>

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Bibliographic Details
Main Author:	Harini Ganeshan (83061) (author)
Other Authors:	Jun Huang (127297) (author), Maria Belmonte (201939) (author), Arnel Belmonte (818807) (author), Sandra Inoue (8985857) (author), Rachel Velasco (8843570) (author), Santina Maiolatesi (201913) (author), Keith Limbach (173085) (author), Noelle Patterson (282154) (author), Marvin J. Sklar (11408465) (author), Lorraine Soisson (69549) (author), Judith E. Epstein (8985875) (author), Kimberly A. Edgel (106388) (author), Bjoern Peters (19131) (author), Michael R. Hollingdale (8843579) (author), Eileen Villasante (628418) (author), Christopher A. Duplessis (4432813) (author), Martha Sedegah (201887) (author)
Published:	2025
Subjects:	Medicine Genetics Molecular Biology Biotechnology Immunology Cancer Infectious Diseases Virology plasmodium falciparum </ ifn -&# 947 genetically diverse population fluorospot interferon gamma based vaccine trial discuss possible reasons 12 subpools ), 11 subpools ). related adhesion protein develop robust assays specific positive subpools specific peptide subpools strongly positive antigen five recalled responses determine whether responses assays using antigen protected participants confirming human adenovirus 5 chimpanzee adenovirus 63 predicted mhc class predicted additional epitopes restricted epitopes within epitope malaria vaccines malaria multiple epitopes xlink "> protected assess possible association ama1 15mer subpools antigen vaccine dna different hla alleles associated minimal epitopes trap mhc class two recalled responses mhc class protected participants chimpanzee adenovirus xlink "> predicted epitopes develop vaccines restricted epitopes human responses specific 15mers possible contribution antigen dna hla alleles circumsporozoite protein tested epitopes associated epitopes strong responses similar responses individual antigen upon testing results suggest previous gene open label high magnitudes granzyme b future studies confirmed ama1 analysis concentrated also contributed active 15mers
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Cohort CAT: FluoroSpot IFN-γ and GzB responses for non-protected participant v33 (HLA A*23:01 (A24)/A*33:03 (A03), B*51:01 (B07)/B*58:01 (B58) to AMA1 Ap4, Ap8 and Ap10 peptide pools, 15mer peptides, and synthesized predicted epitopes.

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Cohort CAT: FluoroSpot IFN-γ and GzB responses for non-protected participant v33 (HLA A23:01 (A24)/A33:03 (A03), B51:01 (B07)/B58:01 (B58) to AMA1 Ap4, Ap8 and Ap10 peptide pools, 15mer peptides, and synthesized predicted epitopes.