Animation displaying S100A1−MDM2 complex generated via the HADDOCK program.

Animation displaying S100A1−MDM2 complex generated via the HADDOCK program.

<p>S100A1 is painted in green and MDM2 in yellow color. Residues neighboring the interface regions are indicated in red (from the S100A1 side) and blue (from MDM2 side), respectively.</p>

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Bibliographic Details
Main Author:	Deepu Dowarha (5673440) (author)
Other Authors:	Ruey-Hwang Chou (151749) (author), Chin Yu (607510) (author)
Published:	2020
Subjects:	Biophysics Biochemistry Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer Virology Biological Sciences not elsewhere classified decreases cell proliferation activity S 100A segment S 100A blocks p 53 Peptide 1 p 53-TAD p 53-MDM interaction cell cycle arrest N-terminal domain p 53-MDM association p 53 functions MDM 2-mediated degradation MCF -7 cells cell-penetrating HIV-TAT peptide S 100A protein cancer cells apoptotic cell death NMR p 53 N-terminal domain type p 53 pathway HADDOCK 17- residue peptide HSQC-NMR MDM 2 p 53 protein p 53 gene p 53 tumor suppressor capability S 100A
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