Experimental protocol.

<div><p>The treatment of <i>Mycobacterium avium</i> infections is still long, complex, and often poorly tolerated, besides emergence of resistances. New active molecules that are more effective and better tolerated are deeply needed. Mefloquine and its enantiomers ((+) Erythr...

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Bibliographic Details
Main Author:	Antoine Froment (19762213) (author)
Other Authors:	Julia Delomez (19762216) (author), Sophie Da Nascimento (8220786) (author), Alexandra Dassonville-Klimpt (19343707) (author), Claire Andréjak (11721492) (author), François Peltier (19762219) (author), Cédric Joseph (19762222) (author), Pascal Sonnet (2570548) (author), Jean-Philippe Lanoix (1604716) (author)
Published:	2024
Subjects:	Biochemistry Biotechnology Immunology Cancer Infectious Diseases Virology Computational Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified new active molecules 83 ± 0 82 ± 0 70 ± 0 43 ± 0 often poorly tolerated lowest cfu count emb -(-)- emq emb -(+)- emq div >< p clarithromycin resistant strains 26 ), rif 18 ), mfq mefloquine ((+)- emq mycobacterium avium </ enantiomers ((+) erythro group 3 months gold standard treatment evaluate drug efficacy 15 ), clr 3 months (+)- emq better tolerated avium </ (-)- erythro emb group vivo </ vitro </ untreated group treatment groups time point still long significant difference shown efficacy prevent selection murine model mouse model lung homogenates enantiomers appear c mice besides emergence aerosol model 5 mice 25 ). 21 ). 005 ).
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Experimental protocol.

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