Inhibitory effect of 6-phosphogluconate (6-PG) on NagS.

Inhibitory effect of 6-phosphogluconate (6-PG) on NagS.

<p>(<b>a</b>) Chemical structures of 6-PG and linear GlcNAc-6P. (<b>b</b>) Average <i>T</i><sub>m</sub> curve of NagS in presence of 6-PG. Melting curve of 4 µM NagS (black), 4 µM NagS with 2 mM 6-PG (large dash), 5 mM 6-PG (dot), and 10mM 6-PG (...

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Збережено в:
Бібліографічні деталі
Автор: Chao Li (145513) (author)
Інші автори: Mia Urem (22683580) (author), Ioli Kotsogianni (9930187) (author), Josephine Lau (20442343) (author), Chao Du (288036) (author), Somayah S. Elsayed (9192571) (author), Nathaniel I. Martin (847378) (author), Iain W. McNae (840777) (author), Patrick Voskamp (2311429) (author), Christoph Mayer (57204) (author), Sébastien Rigali (724082) (author), Navraj Pannu (10163763) (author), Jan Pieter Abrahams (1429531) (author), Lennart Schada von Borzyskowski (22683583) (author), Gilles P. van Wezel (7838948) (author)
Опубліковано: 2025
Предмети:
Biochemistry
Microbiology
Ecology
Developmental Biology
Inorganic Chemistry
Biological Sciences not elsewhere classified
controls nutrient signaling
also revealed 6
highlighted key residues
glcnac sensing requires
toxicity pathway dependent
6p deacetylase naga
novel glcnac 6
key role
substrate glcnac
novel enzyme
work uncovers
wall leads
unprecedented reaction
substrate mycelium
structural analogue
streptomycetaceae </
streptomyces </
revolves around
promiscuous activity
nature ’
n </
multicellular lifestyle
metabolic checkpoint
medicine makers
lytic dismantling
landmark event
hyphal cell
highly conserved
growth media
function analysis
clinical antibiotics
central metabolism
catalytic inhibitor
antibiotic production
active site
>- acetylglucosamine
6p dehydratase
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