Inhibitory effect of 6-phosphogluconate (6-PG) on NagS.

Inhibitory effect of 6-phosphogluconate (6-PG) on NagS.

<p>(<b>a</b>) Chemical structures of 6-PG and linear GlcNAc-6P. (<b>b</b>) Average <i>T</i><sub>m</sub> curve of NagS in presence of 6-PG. Melting curve of 4 µM NagS (black), 4 µM NagS with 2 mM 6-PG (large dash), 5 mM 6-PG (dot), and 10mM 6-PG (...

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Autor principal:	Chao Li (145513) (author)
Altres autors:	Mia Urem (22683580) (author), Ioli Kotsogianni (9930187) (author), Josephine Lau (20442343) (author), Chao Du (288036) (author), Somayah S. Elsayed (9192571) (author), Nathaniel I. Martin (847378) (author), Iain W. McNae (840777) (author), Patrick Voskamp (2311429) (author), Christoph Mayer (57204) (author), Sébastien Rigali (724082) (author), Navraj Pannu (10163763) (author), Jan Pieter Abrahams (1429531) (author), Lennart Schada von Borzyskowski (22683583) (author), Gilles P. van Wezel (7838948) (author)
Publicat:	2025
Matèries:	Biochemistry Microbiology Ecology Developmental Biology Inorganic Chemistry Biological Sciences not elsewhere classified controls nutrient signaling also revealed 6 highlighted key residues glcnac sensing requires toxicity pathway dependent 6p deacetylase naga novel glcnac 6 key role substrate glcnac novel enzyme work uncovers wall leads unprecedented reaction substrate mycelium structural analogue streptomycetaceae </ streptomyces </ revolves around promiscuous activity nature ’ n </ multicellular lifestyle metabolic checkpoint medicine makers lytic dismantling landmark event hyphal cell highly conserved growth media function analysis clinical antibiotics central metabolism catalytic inhibitor antibiotic production active site >- acetylglucosamine 6p dehydratase
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