TTR CZE FPPHR Fragment Hits.

<div><p>A Capillary Zone Electrophoresis (CZE) fragment screening methodology was developed and applied to the human plasma protein Transthyretin (TTR), normally soluble, but could misfold and aggregate, causing amyloidosis. Termed Free Probe Peak Height Restoration (FPPHR), it monitors...

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Bibliographic Details
Main Author:	Wenjie Chen (130753) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Molecular Biology Neuroscience Pharmacology Biotechnology Cancer Infectious Diseases Chemical Sciences not elsewhere classified two lead molecules thyroxine displacement ic thyroxine displacement assay subsequent analogue screens capillary zone electrophoresis 16 initial hits free ligand known confirmation rate ). based drug discovery similar itc k div >< p 125 </ sup fragment screening methodology probe ligand hit rate fragment screening fluorescence based </ sub xlink "> transthyretin amyloidosis procedurally simple neat plasma monitors changes fpphr ), derived compounds competing fragments circular dichroism causing amyloidosis 129 fragments
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TTR CZE FPPHR Fragment Hits.

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