Discontinuous transcription in coronaviruses.

(A) Schematic of the SARS-CoV-2 genome and (B) the mechanism of discontinuous transcription for expression of the structural (S, E, M, N) and accessory genes (yellow highlight). (C) Alignment of TRS-Bs upstream of each of the indicate...

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Bibliographic Details
Main Author:	Harriet V. Mears (17873605) (author)
Other Authors:	George R. Young (8893355) (author), Theo Sanderson (5662720) (author), Ruth Harvey (323318) (author), Jamie Barrett-Rodger (20592217) (author), Rebecca Penn (9979944) (author), Vanessa Cowton (13189782) (author), Wilhelm Furnon (10196183) (author), Giuditta De Lorenzo (552196) (author), Margaret Crawford (11903252) (author), Daniel M. Snell (20592223) (author), Ashley S. Fowler (17873602) (author), Anob M. Chakrabarti (20144324) (author), Saira Hussain (8268135) (author), Ciarán Gilbride (20592226) (author), Edward Emmott (493404) (author), Katja Finsterbusch (544282) (author), Jakub Luptak (9415797) (author), Thomas P. Peacock (6536120) (author), Jérôme Nicod (214878) (author), Arvind H. Patel (10196255) (author), Massimo Palmarini (81656) (author), Emma Wall (12895910) (author), Bryan Williams (4283011) (author), Sonia Gandhi (49260) (author), Charles Swanton (236153) (author), David L. V. Bauer (17873608) (author)
Published:	2025
Subjects:	Medicine Microbiology Genetics Molecular Biology Evolutionary Biology Cancer Mental Health Infectious Diseases Virology Computational Biology undergoing evolutionary changes orf1b &# 8212 observe distinct phenotypes functional rna level accessory genes via 5 &# 8242 3 &# 8242 transcription regulatory sequences nsp16 coding region supported examples upstream enhance viral fitness nucleocapsid coding sequence 2 subgenomic rnas coding region viral fitness subgenomic rnas 2 sequences whose synthesis upon searching truncated c terminal portion show well nucleocapsid gene mutated compared multiple lineages interferon production genomic leader frequent neo evolves frequently evolved convergently descendants thereof consensus aaacgaac concern alpha
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Discontinuous transcription in coronaviruses.

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