Discontinuous transcription in coronaviruses.
<p><b>(A)</b> Schematic of the SARS-CoV-2 genome and <b>(B)</b> the mechanism of discontinuous transcription for expression of the structural (S, E, M, N) and accessory genes (yellow highlight). <b>(C)</b> Alignment of TRS-Bs upstream of each of the indicate...
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2025
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| _version_ | 1852023407394160640 |
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| author | Harriet V. Mears (17873605) |
| author2 | George R. Young (8893355) Theo Sanderson (5662720) Ruth Harvey (323318) Jamie Barrett-Rodger (20592217) Rebecca Penn (9979944) Vanessa Cowton (13189782) Wilhelm Furnon (10196183) Giuditta De Lorenzo (552196) Margaret Crawford (11903252) Daniel M. Snell (20592223) Ashley S. Fowler (17873602) Anob M. Chakrabarti (20144324) Saira Hussain (8268135) Ciarán Gilbride (20592226) Edward Emmott (493404) Katja Finsterbusch (544282) Jakub Luptak (9415797) Thomas P. Peacock (6536120) Jérôme Nicod (214878) Arvind H. Patel (10196255) Massimo Palmarini (81656) Emma Wall (12895910) Bryan Williams (4283011) Sonia Gandhi (49260) Charles Swanton (236153) David L. V. Bauer (17873608) |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Harriet V. Mears (17873605) George R. Young (8893355) Theo Sanderson (5662720) Ruth Harvey (323318) Jamie Barrett-Rodger (20592217) Rebecca Penn (9979944) Vanessa Cowton (13189782) Wilhelm Furnon (10196183) Giuditta De Lorenzo (552196) Margaret Crawford (11903252) Daniel M. Snell (20592223) Ashley S. Fowler (17873602) Anob M. Chakrabarti (20144324) Saira Hussain (8268135) Ciarán Gilbride (20592226) Edward Emmott (493404) Katja Finsterbusch (544282) Jakub Luptak (9415797) Thomas P. Peacock (6536120) Jérôme Nicod (214878) Arvind H. Patel (10196255) Massimo Palmarini (81656) Emma Wall (12895910) Bryan Williams (4283011) Sonia Gandhi (49260) Charles Swanton (236153) David L. V. Bauer (17873608) |
| author_role | author |
| dc.creator.none.fl_str_mv | Harriet V. Mears (17873605) George R. Young (8893355) Theo Sanderson (5662720) Ruth Harvey (323318) Jamie Barrett-Rodger (20592217) Rebecca Penn (9979944) Vanessa Cowton (13189782) Wilhelm Furnon (10196183) Giuditta De Lorenzo (552196) Margaret Crawford (11903252) Daniel M. Snell (20592223) Ashley S. Fowler (17873602) Anob M. Chakrabarti (20144324) Saira Hussain (8268135) Ciarán Gilbride (20592226) Edward Emmott (493404) Katja Finsterbusch (544282) Jakub Luptak (9415797) Thomas P. Peacock (6536120) Jérôme Nicod (214878) Arvind H. Patel (10196255) Massimo Palmarini (81656) Emma Wall (12895910) Bryan Williams (4283011) Sonia Gandhi (49260) Charles Swanton (236153) David L. V. Bauer (17873608) |
| dc.date.none.fl_str_mv | 2025-01-21T18:40:22Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pbio.3002982.g001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Discontinuous_transcription_in_coronaviruses_/28250410 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medicine Microbiology Genetics Molecular Biology Evolutionary Biology Cancer Mental Health Infectious Diseases Virology Computational Biology undergoing evolutionary changes orf1b &# 8212 observe distinct phenotypes functional rna level accessory genes via 5 &# 8242 3 &# 8242 transcription regulatory sequences nsp16 coding region supported examples upstream enhance viral fitness nucleocapsid coding sequence 2 subgenomic rnas coding region viral fitness subgenomic rnas 2 sequences whose synthesis upon searching truncated c terminal portion show well nucleocapsid gene mutated compared multiple lineages interferon production genomic leader frequent neo evolves frequently evolved convergently descendants thereof consensus aaacgaac concern alpha |
| dc.title.none.fl_str_mv | Discontinuous transcription in coronaviruses. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><b>(A)</b> Schematic of the SARS-CoV-2 genome and <b>(B)</b> the mechanism of discontinuous transcription for expression of the structural (S, E, M, N) and accessory genes (yellow highlight). <b>(C)</b> Alignment of TRS-Bs upstream of each of the indicated ORFs, compared to the TRS-L. Regions of homology to the TRS-L are highlighted in blue and downstream homology to the 5′UTR is highlighted in green. TRS, transcription regulatory sequence.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_cd873d3f0fbb5a2d9fd38564b939941f |
| identifier_str_mv | 10.1371/journal.pbio.3002982.g001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/28250410 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Discontinuous transcription in coronaviruses.Harriet V. Mears (17873605)George R. Young (8893355)Theo Sanderson (5662720)Ruth Harvey (323318)Jamie Barrett-Rodger (20592217)Rebecca Penn (9979944)Vanessa Cowton (13189782)Wilhelm Furnon (10196183)Giuditta De Lorenzo (552196)Margaret Crawford (11903252)Daniel M. Snell (20592223)Ashley S. Fowler (17873602)Anob M. Chakrabarti (20144324)Saira Hussain (8268135)Ciarán Gilbride (20592226)Edward Emmott (493404)Katja Finsterbusch (544282)Jakub Luptak (9415797)Thomas P. Peacock (6536120)Jérôme Nicod (214878)Arvind H. Patel (10196255)Massimo Palmarini (81656)Emma Wall (12895910)Bryan Williams (4283011)Sonia Gandhi (49260)Charles Swanton (236153)David L. V. Bauer (17873608)MedicineMicrobiologyGeneticsMolecular BiologyEvolutionary BiologyCancerMental HealthInfectious DiseasesVirologyComputational Biologyundergoing evolutionary changesorf1b &# 8212observe distinct phenotypesfunctional rna levelaccessory genes via5 &# 82423 &# 8242transcription regulatory sequencesnsp16 coding regionsupported examples upstreamenhance viral fitnessnucleocapsid coding sequence2 subgenomic rnascoding regionviral fitnesssubgenomic rnas2 sequenceswhose synthesisupon searchingtruncated cterminal portionshow wellnucleocapsid genemutated comparedmultiple lineagesinterferon productiongenomic leaderfrequent neoevolves frequentlyevolved convergentlydescendants thereofconsensus aaacgaacconcern alpha<p><b>(A)</b> Schematic of the SARS-CoV-2 genome and <b>(B)</b> the mechanism of discontinuous transcription for expression of the structural (S, E, M, N) and accessory genes (yellow highlight). <b>(C)</b> Alignment of TRS-Bs upstream of each of the indicated ORFs, compared to the TRS-L. Regions of homology to the TRS-L are highlighted in blue and downstream homology to the 5′UTR is highlighted in green. TRS, transcription regulatory sequence.</p>2025-01-21T18:40:22ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pbio.3002982.g001https://figshare.com/articles/figure/Discontinuous_transcription_in_coronaviruses_/28250410CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/282504102025-01-21T18:40:22Z |
| spellingShingle | Discontinuous transcription in coronaviruses. Harriet V. Mears (17873605) Medicine Microbiology Genetics Molecular Biology Evolutionary Biology Cancer Mental Health Infectious Diseases Virology Computational Biology undergoing evolutionary changes orf1b &# 8212 observe distinct phenotypes functional rna level accessory genes via 5 &# 8242 3 &# 8242 transcription regulatory sequences nsp16 coding region supported examples upstream enhance viral fitness nucleocapsid coding sequence 2 subgenomic rnas coding region viral fitness subgenomic rnas 2 sequences whose synthesis upon searching truncated c terminal portion show well nucleocapsid gene mutated compared multiple lineages interferon production genomic leader frequent neo evolves frequently evolved convergently descendants thereof consensus aaacgaac concern alpha |
| status_str | publishedVersion |
| title | Discontinuous transcription in coronaviruses. |
| title_full | Discontinuous transcription in coronaviruses. |
| title_fullStr | Discontinuous transcription in coronaviruses. |
| title_full_unstemmed | Discontinuous transcription in coronaviruses. |
| title_short | Discontinuous transcription in coronaviruses. |
| title_sort | Discontinuous transcription in coronaviruses. |
| topic | Medicine Microbiology Genetics Molecular Biology Evolutionary Biology Cancer Mental Health Infectious Diseases Virology Computational Biology undergoing evolutionary changes orf1b &# 8212 observe distinct phenotypes functional rna level accessory genes via 5 &# 8242 3 &# 8242 transcription regulatory sequences nsp16 coding region supported examples upstream enhance viral fitness nucleocapsid coding sequence 2 subgenomic rnas coding region viral fitness subgenomic rnas 2 sequences whose synthesis upon searching truncated c terminal portion show well nucleocapsid gene mutated compared multiple lineages interferon production genomic leader frequent neo evolves frequently evolved convergently descendants thereof consensus aaacgaac concern alpha |