Tumor features.

<div><p>Combined hepatocellular carcinoma-cholangiocarcinoma (HCC-CCA) is a rare liver tumor comprising histologic features of both HCC and CCA. Due to its heterogeneous nature, treatment of combined HCC-CCA is a significant clinical challenge and prognosis remains poor. Therefore, furth...

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Bibliographic Details
Main Author:	Kyle M. Schachtschneider (10717923) (author)
Other Authors:	Luke N. Redlon (21433583) (author), Ryan Peter Lokken (21433586) (author), Yu-Hui Huang (3092457) (author), Grace Guzman (7924208) (author), Lawrence B. Schook (24663) (author), Ron C. Gaba (1910662) (author)
Published:	2025
Subjects:	Biochemistry Genetics Molecular Biology Immunology Cancer Plant Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified significant clinical challenge differential analysis resulted adjacent unstained slides 9 patients diagnosed optimize treatment strategies improve treatment stratification prognosis remains poor tumor biology underlying gene expression patterns wide dna methylation cca tumor biology cholangiocarcinoma </ p gene expression dna methylation 5 patients tumor type tumor specimens tumor aggressiveness mixed tumor increased expression underlying hcc treatment responses wnt signaling results highlight regions representative potential importance optimal course metal binding individual components heterogeneous nature genetic background gated channels epigenetic regulation comparing genome combined hepatocellular cellular regulation cca components cancer subtype 8 cca 7 cca 4 clustered
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Tumor features.

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