Supplementary Figure 5 from <i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma

Supplementary Figure 5 from <i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma

<p>Supplementary Figure 5: Single-cell RNA Sequencing and IHC examination of ALK in human neural development and immature neural cells. A. 2D representation of human brain cell subtypes (48 samples) during cortex development using a single cell RNA-seq atlas (cortex-dev.cells.ucsc.edu) shows t...

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Auteur principal: Anne-Florence Blandin (15056366) (author)
Autres auteurs: Ross Giglio (15056369) (author), Maya Srikanth Graham (15056372) (author), Guadalupe Garcia (15056375) (author), Seth Malinowski (15056378) (author), Jared K. Woods (15056381) (author), Shakti Ramkissoon (15056384) (author), Lori Ramkissoon (15056387) (author), Frank Dubois (15056390) (author), Kathleen Schoolcraft (15056393) (author), Jessica Tsai (15056396) (author), Dayle Wang (15056399) (author), Robert Jones (15056402) (author), Jayne Vogelzang (15056405) (author), Kristine Pelton (15056408) (author), Sarah Becker (15056411) (author), Fiona Watkinson (15056414) (author), Claire Sinai (15056417) (author), Elizabeth F. Cohen (15056420) (author), Matthew A. Booker (15056423) (author), Michael Y. Tolstorukov (15056426) (author), Veerle Haemels (15056429) (author), Liliana Goumnerova (15056432) (author), Karen Wright (15056435) (author), Mark Kieran (15056438) (author), Katie Fehnel (15056441) (author), David Reardon (15056444) (author), Arnault Tauziede-Espariat (15056447) (author), Rishi Lulla (15056450) (author), Benjamin Carcamo (15056453) (author), Stanley Chaleff (15056456) (author), Alain Charest (15056459) (author), Frederik De Smet (14957559) (author), Azra H. Ligon (15056462) (author), Adrian Dubuc (15056465) (author), Melanie Pages (15056468) (author), Pascale Varlet (15056471) (author), Patrick Y. Wen (15056474) (author), Brian M. Alexander (15019467) (author), Susan Chi (15056477) (author), Sanda Alexandrescu (9122099) (author), Ralf Kittler (14864988) (author), Robert Bachoo (15056480) (author), Pratiti Bandopadhayay (15056483) (author), Rameen Beroukhim (15056486) (author), Keith L. Ligon (14958845) (author)
Publié: 2025
Sujets:
Cancer
Cancer Biology
Molecular and Cellular Biology
Cancer Detection and Diagnosis
Therapeutic Research and Development
Methods and Technology
Biomarkers
Cell Signaling
Receptors
CNS Cancers
Gliomas, Glioblastomas
Drug Targets
Protein kinase & phosphatase drug targets
Oncogenes & Tumor Suppressors
Oncogenes
Pediatric Cancers
Preclinical Models
Xenograft models
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Résumé:<p>Supplementary Figure 5: Single-cell RNA Sequencing and IHC examination of ALK in human neural development and immature neural cells. A. 2D representation of human brain cell subtypes (48 samples) during cortex development using a single cell RNA-seq atlas (cortex-dev.cells.ucsc.edu) shows that ALK transcript appears to be enriched in a certain cell type. Color-coded by ALK gene expression (beige to red) and age in weeks (rainbow).B. ALK-stained sagittal section of normal human cerebellum at 15 postconceptional weeks (pcw).C. ALK-stained sagittal section of human fetal neural stem cell pellets at 13 postconceptional weeks (pcw).D. ALK-stained sagittal section of human fetal neural stem cell pellets at 15 postconceptional weeks (pcw).</p>

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