Supplementary Figure 5 from <i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma
<p>Supplementary Figure 5: Single-cell RNA Sequencing and IHC examination of ALK in human neural development and immature neural cells. A. 2D representation of human brain cell subtypes (48 samples) during cortex development using a single cell RNA-seq atlas (cortex-dev.cells.ucsc.edu) shows t...
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2025
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| _version_ | 1849927632897966080 |
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| author | Anne-Florence Blandin (15056366) |
| author2 | Ross Giglio (15056369) Maya Srikanth Graham (15056372) Guadalupe Garcia (15056375) Seth Malinowski (15056378) Jared K. Woods (15056381) Shakti Ramkissoon (15056384) Lori Ramkissoon (15056387) Frank Dubois (15056390) Kathleen Schoolcraft (15056393) Jessica Tsai (15056396) Dayle Wang (15056399) Robert Jones (15056402) Jayne Vogelzang (15056405) Kristine Pelton (15056408) Sarah Becker (15056411) Fiona Watkinson (15056414) Claire Sinai (15056417) Elizabeth F. Cohen (15056420) Matthew A. Booker (15056423) Michael Y. Tolstorukov (15056426) Veerle Haemels (15056429) Liliana Goumnerova (15056432) Karen Wright (15056435) Mark Kieran (15056438) Katie Fehnel (15056441) David Reardon (15056444) Arnault Tauziede-Espariat (15056447) Rishi Lulla (15056450) Benjamin Carcamo (15056453) Stanley Chaleff (15056456) Alain Charest (15056459) Frederik De Smet (14957559) Azra H. Ligon (15056462) Adrian Dubuc (15056465) Melanie Pages (15056468) Pascale Varlet (15056471) Patrick Y. Wen (15056474) Brian M. Alexander (15019467) Susan Chi (15056477) Sanda Alexandrescu (9122099) Ralf Kittler (14864988) Robert Bachoo (15056480) Pratiti Bandopadhayay (15056483) Rameen Beroukhim (15056486) Keith L. Ligon (14958845) |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Anne-Florence Blandin (15056366) Ross Giglio (15056369) Maya Srikanth Graham (15056372) Guadalupe Garcia (15056375) Seth Malinowski (15056378) Jared K. Woods (15056381) Shakti Ramkissoon (15056384) Lori Ramkissoon (15056387) Frank Dubois (15056390) Kathleen Schoolcraft (15056393) Jessica Tsai (15056396) Dayle Wang (15056399) Robert Jones (15056402) Jayne Vogelzang (15056405) Kristine Pelton (15056408) Sarah Becker (15056411) Fiona Watkinson (15056414) Claire Sinai (15056417) Elizabeth F. Cohen (15056420) Matthew A. Booker (15056423) Michael Y. Tolstorukov (15056426) Veerle Haemels (15056429) Liliana Goumnerova (15056432) Karen Wright (15056435) Mark Kieran (15056438) Katie Fehnel (15056441) David Reardon (15056444) Arnault Tauziede-Espariat (15056447) Rishi Lulla (15056450) Benjamin Carcamo (15056453) Stanley Chaleff (15056456) Alain Charest (15056459) Frederik De Smet (14957559) Azra H. Ligon (15056462) Adrian Dubuc (15056465) Melanie Pages (15056468) Pascale Varlet (15056471) Patrick Y. Wen (15056474) Brian M. Alexander (15019467) Susan Chi (15056477) Sanda Alexandrescu (9122099) Ralf Kittler (14864988) Robert Bachoo (15056480) Pratiti Bandopadhayay (15056483) Rameen Beroukhim (15056486) Keith L. Ligon (14958845) |
| author_role | author |
| dc.creator.none.fl_str_mv | Anne-Florence Blandin (15056366) Ross Giglio (15056369) Maya Srikanth Graham (15056372) Guadalupe Garcia (15056375) Seth Malinowski (15056378) Jared K. Woods (15056381) Shakti Ramkissoon (15056384) Lori Ramkissoon (15056387) Frank Dubois (15056390) Kathleen Schoolcraft (15056393) Jessica Tsai (15056396) Dayle Wang (15056399) Robert Jones (15056402) Jayne Vogelzang (15056405) Kristine Pelton (15056408) Sarah Becker (15056411) Fiona Watkinson (15056414) Claire Sinai (15056417) Elizabeth F. Cohen (15056420) Matthew A. Booker (15056423) Michael Y. Tolstorukov (15056426) Veerle Haemels (15056429) Liliana Goumnerova (15056432) Karen Wright (15056435) Mark Kieran (15056438) Katie Fehnel (15056441) David Reardon (15056444) Arnault Tauziede-Espariat (15056447) Rishi Lulla (15056450) Benjamin Carcamo (15056453) Stanley Chaleff (15056456) Alain Charest (15056459) Frederik De Smet (14957559) Azra H. Ligon (15056462) Adrian Dubuc (15056465) Melanie Pages (15056468) Pascale Varlet (15056471) Patrick Y. Wen (15056474) Brian M. Alexander (15019467) Susan Chi (15056477) Sanda Alexandrescu (9122099) Ralf Kittler (14864988) Robert Bachoo (15056480) Pratiti Bandopadhayay (15056483) Rameen Beroukhim (15056486) Keith L. Ligon (14958845) |
| dc.date.none.fl_str_mv | 2025-11-25T13:11:23Z |
| dc.identifier.none.fl_str_mv | 10.1158/1078-0432.30708081 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Supplementary_Figure_5_from_i_ALK_i_Amplification_and_Rearrangements_Are_Recurrent_Targetable_Events_in_Congenital_and_Adult_Glioblastoma/30708081 |
| dc.rights.none.fl_str_mv | CC BY info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cancer Cancer Biology Molecular and Cellular Biology Cancer Detection and Diagnosis Therapeutic Research and Development Methods and Technology Biomarkers Cell Signaling Receptors CNS Cancers Gliomas, Glioblastomas Drug Targets Protein kinase & phosphatase drug targets Oncogenes & Tumor Suppressors Oncogenes Pediatric Cancers Preclinical Models Xenograft models |
| dc.title.none.fl_str_mv | Supplementary Figure 5 from <i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Supplementary Figure 5: Single-cell RNA Sequencing and IHC examination of ALK in human neural development and immature neural cells. A. 2D representation of human brain cell subtypes (48 samples) during cortex development using a single cell RNA-seq atlas (cortex-dev.cells.ucsc.edu) shows that ALK transcript appears to be enriched in a certain cell type. Color-coded by ALK gene expression (beige to red) and age in weeks (rainbow).B. ALK-stained sagittal section of normal human cerebellum at 15 postconceptional weeks (pcw).C. ALK-stained sagittal section of human fetal neural stem cell pellets at 13 postconceptional weeks (pcw).D. ALK-stained sagittal section of human fetal neural stem cell pellets at 15 postconceptional weeks (pcw).</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_cdc02f890f826dbcebbbda2223de6518 |
| identifier_str_mv | 10.1158/1078-0432.30708081 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30708081 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY |
| spelling | Supplementary Figure 5 from <i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult GlioblastomaAnne-Florence Blandin (15056366)Ross Giglio (15056369)Maya Srikanth Graham (15056372)Guadalupe Garcia (15056375)Seth Malinowski (15056378)Jared K. Woods (15056381)Shakti Ramkissoon (15056384)Lori Ramkissoon (15056387)Frank Dubois (15056390)Kathleen Schoolcraft (15056393)Jessica Tsai (15056396)Dayle Wang (15056399)Robert Jones (15056402)Jayne Vogelzang (15056405)Kristine Pelton (15056408)Sarah Becker (15056411)Fiona Watkinson (15056414)Claire Sinai (15056417)Elizabeth F. Cohen (15056420)Matthew A. Booker (15056423)Michael Y. Tolstorukov (15056426)Veerle Haemels (15056429)Liliana Goumnerova (15056432)Karen Wright (15056435)Mark Kieran (15056438)Katie Fehnel (15056441)David Reardon (15056444)Arnault Tauziede-Espariat (15056447)Rishi Lulla (15056450)Benjamin Carcamo (15056453)Stanley Chaleff (15056456)Alain Charest (15056459)Frederik De Smet (14957559)Azra H. Ligon (15056462)Adrian Dubuc (15056465)Melanie Pages (15056468)Pascale Varlet (15056471)Patrick Y. Wen (15056474)Brian M. Alexander (15019467)Susan Chi (15056477)Sanda Alexandrescu (9122099)Ralf Kittler (14864988)Robert Bachoo (15056480)Pratiti Bandopadhayay (15056483)Rameen Beroukhim (15056486)Keith L. Ligon (14958845)CancerCancer BiologyMolecular and Cellular BiologyCancer Detection and DiagnosisTherapeutic Research and DevelopmentMethods and TechnologyBiomarkersCell SignalingReceptorsCNS CancersGliomas, GlioblastomasDrug TargetsProtein kinase & phosphatase drug targetsOncogenes & Tumor SuppressorsOncogenesPediatric CancersPreclinical ModelsXenograft models<p>Supplementary Figure 5: Single-cell RNA Sequencing and IHC examination of ALK in human neural development and immature neural cells. A. 2D representation of human brain cell subtypes (48 samples) during cortex development using a single cell RNA-seq atlas (cortex-dev.cells.ucsc.edu) shows that ALK transcript appears to be enriched in a certain cell type. Color-coded by ALK gene expression (beige to red) and age in weeks (rainbow).B. ALK-stained sagittal section of normal human cerebellum at 15 postconceptional weeks (pcw).C. ALK-stained sagittal section of human fetal neural stem cell pellets at 13 postconceptional weeks (pcw).D. ALK-stained sagittal section of human fetal neural stem cell pellets at 15 postconceptional weeks (pcw).</p>2025-11-25T13:11:23ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/1078-0432.30708081https://figshare.com/articles/figure/Supplementary_Figure_5_from_i_ALK_i_Amplification_and_Rearrangements_Are_Recurrent_Targetable_Events_in_Congenital_and_Adult_Glioblastoma/30708081CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307080812025-11-25T13:11:23Z |
| spellingShingle | Supplementary Figure 5 from <i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma Anne-Florence Blandin (15056366) Cancer Cancer Biology Molecular and Cellular Biology Cancer Detection and Diagnosis Therapeutic Research and Development Methods and Technology Biomarkers Cell Signaling Receptors CNS Cancers Gliomas, Glioblastomas Drug Targets Protein kinase & phosphatase drug targets Oncogenes & Tumor Suppressors Oncogenes Pediatric Cancers Preclinical Models Xenograft models |
| status_str | publishedVersion |
| title | Supplementary Figure 5 from <i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma |
| title_full | Supplementary Figure 5 from <i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma |
| title_fullStr | Supplementary Figure 5 from <i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma |
| title_full_unstemmed | Supplementary Figure 5 from <i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma |
| title_short | Supplementary Figure 5 from <i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma |
| title_sort | Supplementary Figure 5 from <i>ALK</i> Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma |
| topic | Cancer Cancer Biology Molecular and Cellular Biology Cancer Detection and Diagnosis Therapeutic Research and Development Methods and Technology Biomarkers Cell Signaling Receptors CNS Cancers Gliomas, Glioblastomas Drug Targets Protein kinase & phosphatase drug targets Oncogenes & Tumor Suppressors Oncogenes Pediatric Cancers Preclinical Models Xenograft models |