Structural Insights into the Substrate Recognition Mechanism of an ATP-Grasp Peptide-Ligase Producing Diverse Dipeptides Containing Unnatural Amino Acids

ATP-grasp enzymes are involved in many different biological processes of primary and secondary metabolism and catalyze the production of many physiological or medicinally valuable peptides. Here, we report an ATP-grasp enzyme Alb28, from Streptomyces albogriseolus MGR072, which exhibits broad substr...

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المؤلف الرئيسي:	Ya-Qian Yan (20627782) (author)
مؤلفون آخرون:	Si-Yuan Li (699852) (author), Xiao-Na Wu (1268688) (author), Ting Zhou (38572) (author), Jia-Xin Li (1489726) (author), Shu-Xin Huang (20627785) (author), Jian-Ting Zheng (6707330) (author), Jun Xu (45543) (author), Lin-Tai Da (399373) (author), Min-Juan Xu (5701733) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Pharmacology Ecology Inorganic Chemistry Computational Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified streptomyces albogriseolus mgr072 molecular dynamics simulations medicinally valuable peptides existing dipeptide library combining crystallographic studies two structural motifs substrate recognition mechanism grasp enzyme alb28 substrate recognition structural insights grasp peptide grasp enzymes work potentiates thereby capable therapeutic usages strict stereoselectivity site via secondary metabolism mutagenesis assays many physiological greatly expanding future applications enzymatic catalysis critical residues closing motions alb28 responsible
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Structural Insights into the Substrate Recognition Mechanism of an ATP-Grasp Peptide-Ligase Producing Diverse Dipeptides Containing Unnatural Amino Acids

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