Modeling lung cancer AST network and its perturbation with a SOX2 degrader. (A) Lung Cancer AST Network and the corresponding stochastic equations. Parameters are , , , , , , , , with different . The control parameter is . (B) The potential landscape is approximated by simulating a large number of molecules corresponding to concentrations ( samples) with parameter values , , and , respectively representing the adenocarcinoma state, the intermediate state, and the squamous carcinoma state. FOXA2 and SOX2 amounts are chosen to visualize the landscape. (C) Principle of SOX2-targeted degradation by the PROTAC technique. The PROTAC molecule here is designed to recognize SOX2 proteins and to recruit E3 ligases to induce an addition of ubiquitin (Ub) proteins onto SOX2, which causes degradation of SOX2 subsequently. (D) Application of a SOX2 degrader to the squamous carcinoma state () reprogram the AST network back to the adenocarcinoma state. Here the treatment effect of the SOX2 degrad

<p>Modeling lung cancer AST network and its perturbation with a SOX2 degrader. (A) Lung Cancer AST Network and the corresponding stochastic equations. Parameters are , , , , , , , , with different . The control parameter is . (B) The potential landscape is approximated by simulating a large nu...

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