A cartoon of the simplified model of the Abl1 enzyme system.

<p>The states, molecules they bind to, the transitions between states, and the rate constants for each transition are shown. The Abl1 enzyme is represented by the peach-coloured E-shape in both its active (round corners) and inactive (sharp corners) states; the inhibitor is illustrated by the...

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Bibliographic Details
Main Author:	J. Roadnight Sheehan (20141887) (author)
Other Authors:	Astrid S. de Wijn (20141890) (author), Thales Souza Freire (20141893) (author), Ran Friedman (500639) (author)
Published:	2024
Subjects:	Genetics Pharmacology Biotechnology Evolutionary Biology Cancer Hematology Infectious Diseases Plant Biology Virology Chemical Sciences not elsewhere classified product formation rate major clinical obstacle div >< p chronic myeloid leukaemia line treatment occurs three abl1 inhibitors different abl1 inhibitors contest using fold computational dynamic model guide treatment choice enzyme inhibition treatment abl1 inhibitors abl1 enzyme treatment selection various mutation selecting treatments relative decrease positive impact often seen often guided new parameter model based inhibitor combinations fully known difficult task could increase communicable diseases common cause better indicator approximately one &# 8220
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A cartoon of the simplified model of the Abl1 enzyme system.

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