Development of an Intravenously Stable Disulfide-Rich Peptide for the Treatment of Chemotherapy-Induced Neuropathic Pain

Development of an Intravenously Stable Disulfide-Rich Peptide for the Treatment of Chemotherapy-Induced Neuropathic Pain

α-conotoxins (α-Ctxs), a class of disulfide-rich conopetides, are excellent drug leads due to their small size, high selectivity, and potency for specific membrane receptors and ion channels involved in pain transmission. However, their high susceptibility to proteolytic degradation limits their the...

Full description

Saved in:
Bibliographic Details
Main Author: Tianmiao Li (19796984) (author)
Other Authors: Han-Shen Tae (1639798) (author), Shen Chen (1820062) (author), Xiao Li (107004) (author), Jiazhen Liang (8448420) (author), Teng Pan (6550055) (author), Zixuan Zhang (6957035) (author), Tao Jiang (28401) (author), David J. Adams (119198) (author), Rilei Yu (228408) (author)
Published: 2024
Subjects:
Biophysics
Biochemistry
Cell Biology
Genetics
Neuroscience
Pharmacology
Biotechnology
Ecology
Cancer
Hematology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
specific membrane receptors
proteolytic degradation limits
maximal inhibitory concentration
ion channels involved
induced cold allodynia
conformationally stable analogues
future therapeutic applications
serum stability compared
intravenously stable disulfide
analogue maintained potency
serum stability
therapeutic potential
small size
rich peptides
rich peptide
rich conopetides
pain transmission
intravenous application
high susceptibility
high selectivity
high potential
fold increase
ctxs ),
4 nm
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items