Development of an Intravenously Stable Disulfide-Rich Peptide for the Treatment of Chemotherapy-Induced Neuropathic Pain

α-conotoxins (α-Ctxs), a class of disulfide-rich conopetides, are excellent drug leads due to their small size, high selectivity, and potency for specific membrane receptors and ion channels involved in pain transmission. However, their high susceptibility to proteolytic degradation limits their the...

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التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Tianmiao Li (19796984) (author)
مؤلفون آخرون:	Han-Shen Tae (1639798) (author), Shen Chen (1820062) (author), Xiao Li (107004) (author), Jiazhen Liang (8448420) (author), Teng Pan (6550055) (author), Zixuan Zhang (6957035) (author), Tao Jiang (28401) (author), David J. Adams (119198) (author), Rilei Yu (228408) (author)
منشور في:	2024
الموضوعات:	Biophysics Biochemistry Cell Biology Genetics Neuroscience Pharmacology Biotechnology Ecology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified specific membrane receptors proteolytic degradation limits maximal inhibitory concentration ion channels involved induced cold allodynia conformationally stable analogues future therapeutic applications serum stability compared intravenously stable disulfide analogue maintained potency serum stability therapeutic potential small size rich peptides rich peptide rich conopetides pain transmission intravenous application high susceptibility high selectivity high potential fold increase ctxs ), 4 nm
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Development of an Intravenously Stable Disulfide-Rich Peptide for the Treatment of Chemotherapy-Induced Neuropathic Pain

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