<i>DhTmp1</i>, a Zn(II)<sub>2</sub>Cys<sub>6</sub> Transcription Factor, Negatively Regulates Pathogenicity in Dactylellina haptotyla by Repressing Nematocidal Metabolite Biosynthesis

<i>DhTmp1</i>, a Zn(II)<sub>2</sub>Cys<sub>6</sub> Transcription Factor, Negatively Regulates Pathogenicity in Dactylellina haptotyla by Repressing Nematocidal Metabolite Biosynthesis

Fungal pathogenesis and development are regulated by transcription factors. Here, we characterized <i>DhTmp1</i> in the nematode-trapping fungus Dactylellina haptotyla as a negative regulator of predation. Its deletion impaired fungal growth and stress tolerance yet enhanced pathogenicit...

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Bibliographic Details
Main Author: Hong-Mei Lei (6950927) (author)
Other Authors: Guang-Ke Zhang (22667346) (author), Shi-Mei Shen (22667349) (author), Guo-Hong Li (3344780) (author), Pei-Ji Zhao (2060167) (author)
Published: 2025
Subjects:
Biochemistry
Medicine
Microbiology
Cell Biology
Genetics
Biotechnology
Ecology
Developmental Biology
Hematology
Plant Biology
Computational Biology
Chemical Sciences not elsewhere classified
pot experiments demonstrated
negatively regulates pathogenicity
metabolomic analyses revealed
manipulation could optimize
exhibited potent activity
ii )< sub
48 h lc
50 </ sub
2 </ sub
nematocidal metabolites 4
6 </ sub
h </
dhtmp1 </
∼ 20
type strain
treated control
transcription factors
transcription factor
negative regulator
integrated transcriptomic
hydroxy benzaldehyde
findings reveal
dactylellina haptotyla
control efficiency
caenorhabditis elegans
achieved 74
>- indole
71 μg
6 %.
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