Confirm the outcome of the hits from 5JI4 libraries.

Confirm the outcome of the hits from 5JI4 libraries.

<p><b>A.</b> An example of peptide 5ji4-RSP-1 <i>in vitro</i> re-folding. TIC from LC/MS runs before and after re-folding are shown on the left with peaks’ m/z on the right. After two days of re-folding, both peaks 2 and 3 contain expected m/z (indicated by green triang...

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Fei Cai (43088) (author)
مؤلفون آخرون:	Yuehua Wei (1515808) (author), Daniel Kirchhofer (769756) (author), Andrew Chang (578485) (author), Yingnan Zhang (270437) (author)
منشور في:	2024
الموضوعات:	Biophysics Biochemistry Biotechnology Biological Sciences not elsewhere classified Information Systems not elsewhere classified yeast surface display naturally occurring disulfide natural language understanding high accuracy across de novo </ attractive therapeutic modalities alanine scanning experiment good folding properties enhanced folding efficiency highly functional libraries findings could pave exhibiting highly stable work advances peptide utilizing multiple dcps div >< p >- designed hcp discovering peptide therapeutics original library design peptide scaffolds played libraries could spontaneous folding stable topology library design peptide scaffolds developing therapeutics based therapeutics techniques used scale dataset robust platform rapid prediction prediction model poor chemical physical stability model based like scaffolds key residues insights gained first generated emerging modality either agonize efficient development crucial role broad range
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مواد مشابهة

Superimposing the structure of 5JI4 (PDB 5ji4, yellow) and the Alphafold2-predicted structure of HtrA1-A7.
حسب: Fei Cai (43088)
منشور في: (2024)

Validation of newly constructed 5JI4 phage library based on the predicted ES scores.
حسب: Fei Cai (43088)
منشور في: (2024)

Functional and selective inhibitors against HtrA1 generated from 5JI4 libraries.
حسب: Fei Cai (43088)
منشور في: (2024)

Affinity summary for selected positive hits.
حسب: Fei Cai (43088)
منشور في: (2024)

Re-evaluation of DCP libraries reveals design insights for improved hit rates.
حسب: Fei Cai (43088)
منشور في: (2024)

Accuracy of non-touchable residue prediction measured ES scores vs. predicted ES scores.
حسب: Fei Cai (43088)
منشور في: (2024)

Accuracy of non-touchable residue on three new scaffolds from natural peptides.
حسب: Fei Cai (43088)
منشور في: (2024)

Adjusted F1 score of the cross-validation results.
حسب: Fei Cai (43088)
منشور في: (2024)

Comparison of sequence and structure diversity between our method and ProteinMPNN.
حسب: Fei Cai (43088)
منشور في: (2024)

Validation of machine-learning-predicted non-touchable residues for folding using yeast surface display.
حسب: Fei Cai (43088)
منشور في: (2024)

The trained model generalizes the prediction of ES scores to three distinct natural peptides.
حسب: Fei Cai (43088)
منشور في: (2024)

Sequence similarity among nine scaffolds in the training data.
حسب: Fei Cai (43088)
منشور في: (2024)

Sequences and enrichment scores of nine disulfide-rich peptides.
حسب: Fei Cai (43088)
منشور في: (2024)

Shotgun Alanine scanning as an effective method to generate SAR information between sequences and foldability.
حسب: Fei Cai (43088)
منشور في: (2024)

LC-MS data for all synthetic peptides reported in Table 4 and Fig 9A.
حسب: Fei Cai (43088)
منشور في: (2024)

All sequences and phage spot ELISA data for the table summarized in Fig 6C.
حسب: Fei Cai (43088)
منشور في: (2024)

Raw cross-validation results of each multi-class classifier trained on 5X NGS data.
حسب: Fei Cai (43088)
منشور في: (2024)

Library diversity and total sequence diversity for all scaffolds.
حسب: Fei Cai (43088)
منشور في: (2024)

An example of the definition of non-touchable residues.
حسب: Fei Cai (43088)
منشور في: (2024)

Illustration of adjusted label and confusion matrix using the entire cross-validation datasets (9 scaffolds combined).
حسب: Fei Cai (43088)
منشور في: (2024)

Sequences and enrichment scores of nine disulfide-rich peptides.
حسب: Fei Cai (43088)
منشور في: (2024)

Positive and negative controls for FACS sorting of folded vs. unfolded peptides.
حسب: Fei Cai (43088)
منشور في: (2024)

Structural based stability prediction does not correlate with the actual yeast display result.
حسب: Fei Cai (43088)
منشور في: (2024)

Diversity Scale of Library Matters: Impact of mRNA Library Diversity Scales on the Discovery of Macrocyclic Peptides Targeting a Protein by the RaPID System
حسب: Jinxuan Zhao (6933926)
منشور في: (2025)

Development of an Intravenously Stable Disulfide-Rich Peptide for the Treatment of Chemotherapy-Induced Neuropathic Pain
حسب: Tianmiao Li (19796984)
منشور في: (2024)

Development of an Intravenously Stable Disulfide-Rich Peptide for the Treatment of Chemotherapy-Induced Neuropathic Pain
حسب: Tianmiao Li (19796984)
منشور في: (2024)

Development of an Intravenously Stable Disulfide-Rich Peptide for the Treatment of Chemotherapy-Induced Neuropathic Pain
حسب: Tianmiao Li (19796984)
منشور في: (2024)

Engineering of Novel Analogues That Are More Receptor-Selective and Potent than the Native Hormone, Insulin-like Peptide 5 (INSL5)
حسب: Hongkang Wu (11730997)
منشور في: (2024)

Engineering of Novel Analogues That Are More Receptor-Selective and Potent than the Native Hormone, Insulin-like Peptide 5 (INSL5)
حسب: Hongkang Wu (11730997)
منشور في: (2024)

Activity and Safety Optimization of Mesoricin: A Dual-Domain Antifungal Peptide from <i>Mesorhizobium</i> sp.
حسب: Hongwei Zhao (62620)
منشور في: (2025)

Modulable Supramolecular Hydrogels via Co-Assembly Using Cyclic Dipeptides: Influence of One Methyl Group
حسب: Yuki Shintani (17790182)
منشور في: (2025)

<i>De Novo</i> Discovery of α,α-Disubstituted α‑amino Acid-Containing α‑helical Peptides as Competitive PPARγ PPI Inhibitors
حسب: Maxwell Sigal (22561153)
منشور في: (2025)

<i>De Novo</i> Discovery of α,α-Disubstituted α‑amino Acid-Containing α‑helical Peptides as Competitive PPARγ PPI Inhibitors
حسب: Maxwell Sigal (22561153)
منشور في: (2025)

Development of Next Generation Cell-Permeable Peptide Inhibitors for the Oncological Target MAGE-A4
حسب: Jiwoong Lim (12511056)
منشور في: (2025)

N‑Branched Tricyclic Guanidines as Novel Melanocortin‑3 Receptor Agonists and Melanocortin‑4 Receptor Antagonists
حسب: Nicholas A. Weirath (12442346)
منشور في: (2025)

N‑Branched Tricyclic Guanidines as Novel Melanocortin‑3 Receptor Agonists and Melanocortin‑4 Receptor Antagonists
حسب: Nicholas A. Weirath (12442346)
منشور في: (2025)

N‑Branched Tricyclic Guanidines as Novel Melanocortin‑3 Receptor Agonists and Melanocortin‑4 Receptor Antagonists
حسب: Nicholas A. Weirath (12442346)
منشور في: (2025)

N‑Branched Tricyclic Guanidines as Novel Melanocortin‑3 Receptor Agonists and Melanocortin‑4 Receptor Antagonists
حسب: Nicholas A. Weirath (12442346)
منشور في: (2025)

N‑Branched Tricyclic Guanidines as Novel Melanocortin‑3 Receptor Agonists and Melanocortin‑4 Receptor Antagonists
حسب: Nicholas A. Weirath (12442346)
منشور في: (2025)

A Novel Strategy to Rapidly Profile and Quantify High-Risk Host Cell Proteins Using Integrated DDA-PRM-dMRM Mode
حسب: Xuan Xu (781842)
منشور في: (2025)

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