π‑Extended Ru–COUBPY Photosensitizers for <i>In Vivo</i> Anticancer Phototherapy Using One-Photon 780 nm Near-Infrared Light

Photodynamic therapy (PDT) is a promising cancer treatment modality, offering precise spatial and temporal control of drug activation using light. However, clinical translation of current photosensitizers (PSs) is limited by inefficient activation at wavelengths within the phototherapeutic window, e...

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Bibliografiset tiedot
Päätekijä:	Diego Abad-Montero (14186530) (author)
Muut tekijät:	Eduardo Izquierdo-García (19198698) (author), Pierre Mesdom (16647605) (author), Albert Gandioso (1854076) (author), Elena de la Torre-Rubio (22801621) (author), Manel Bosch (345777) (author), Juan Sanz-Villafruela (19796652) (author), Alba Deyà (20730381) (author), Marta Redrado (8855630) (author), Valentin V. Novikov (1341987) (author), José Luis Hernández (20730384) (author), Jorge Galino (20730387) (author), Marta E. Alberto (1753153) (author), Antonio Francés-Monerris (1831534) (author), Gilles Gasser (1405966) (author), Vicente Marchán (1651750) (author)
Julkaistu:	2025
Aiheet:	Biochemistry Cell Biology Physiology Pharmacology Immunology Cancer Science Policy Chemical Sciences not elsewhere classified preferential mitochondrial accumulation offering precise spatial minimized tissue photodamage improved tissue penetration extended coubpy ligands anatomical location depending 780 nm light absorption bands well thus represents one potent nanomolar phototoxicity photon nir activation pdt antitumor activity ru6 </ b reduced absorption photodynamic activity inefficient activation vivo </ via </ wavelengths within vinylogation strategy varying size treating tumors temporal control potential versatility phototherapeutic window novel series nir irradiation lead complex hypoxic tumors first ru findings mark exhibit robust endogenous chromophores efficiently generate demonstrated strong current photosensitizers clinical translation 26 tumors
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π‑Extended Ru–COUBPY Photosensitizers for <i>In Vivo</i> Anticancer Phototherapy Using One-Photon 780 nm Near-Infrared Light

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