The phase regulation of Ca2+-cAMP oscillation and corresponding mathematical modeling.

(A) Schematic showing out-of-phase Ca2+-cAMP oscillation outside the nanodomain and in-phase behavior when localized to AKAP/AC nanodomains. This schematic is designed based on experiments in [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journ...

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Bibliographic Details
Main Author:	Lingxia Qiao (19996756) (author)
Other Authors:	Michael Getz (17692612) (author), Ben Gross (2993145) (author), Brian Tenner (138904) (author), Jin Zhang (53297) (author), Padmini Rangamani (4740435) (author)
Published:	2024
Subjects:	Biophysics Biochemistry Microbiology Cell Biology Genetics Neuroscience Physiology Immunology Cancer Science Policy Biological Sciences not elsewhere classified previous experimental studies key circuit motif incoherent feedforward loop develop computational models adenylyl cyclase 8 two important predictions many cellular functions arbitrary phase difference div >< p camp peak simultaneously 2 +</ sup ac nanodomain formation phase oscillations associated enzymes associated two nanodomains ac nanodomains volume ratio turing pattern time delay spatiotemporal orchestration spatial compartmentation signaling molecules second messengers nanoscale organization low level governs camp give rise findings unveil ensuring compartmentation compartment size cellular surface camp oscillations
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The phase regulation of Ca<sup>2+</sup>-cAMP oscillation and corresponding mathematical modeling.

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