<i>Huwe1</i> is required for Sox2 stimulated degradation of Atoh1.

<i>Huwe1</i> is required for Sox2 stimulated degradation of Atoh1.

<p><b>(A)</b><i>Atoh1</i> mRNA upregulation by Sox2. HEK-293T cells were transfected with the indicated concentrations of <i>Sox2</i> followed by qRT-PCR. Error bars indicate SEM (n = 3 experiments; **p < 0.01, ***p < 0.001). <b>(B)</b> Lys...

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Bibliographic Details
Main Author:	Yen-Fu Cheng (5819855) (author)
Other Authors:	Judith S. Kempfle (11136210) (author), Hao Chiang (297429) (author), Kohsuke Tani (20642883) (author), Quan Wang (31224) (author), Sheng-Hong Chen (3981647) (author), Danielle Lenz (20642886) (author), Wei-Yi Chen (695809) (author), Wenjin Wu (8555481) (author), Marco Petrillo (64342) (author), Albert S. B. Edge (9450119) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Microbiology Cell Biology Genetics Molecular Biology Immunology Developmental Biology Hematology Biological Sciences not elsewhere classified late embryogenesis results extra hair cells cognate e3 ligase cochlear hair cells bhlh transcription factor 3 ’ enhancer regulate atoh1 transcription atoh1 protein increases atoh1 protein despite positive feedback loop helix transcription factor div >< p atoh1 </ sox2 interacts sox2 </ proneural basic powerful initiator overexpression decreased new mechanism knockout early inhibition represents huwe1 loci huwe1 </ direct binding
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