<i>Huwe1</i> is required for Sox2 stimulated degradation of Atoh1.

<i>Huwe1</i> is required for Sox2 stimulated degradation of Atoh1.

<p><b>(A)</b><i>Atoh1</i> mRNA upregulation by Sox2. HEK-293T cells were transfected with the indicated concentrations of <i>Sox2</i> followed by qRT-PCR. Error bars indicate SEM (n = 3 experiments; **p < 0.01, ***p < 0.001). <b>(B)</b> Lys...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Yen-Fu Cheng (5819855) (author)
مؤلفون آخرون: Judith S. Kempfle (11136210) (author), Hao Chiang (297429) (author), Kohsuke Tani (20642883) (author), Quan Wang (31224) (author), Sheng-Hong Chen (3981647) (author), Danielle Lenz (20642886) (author), Wei-Yi Chen (695809) (author), Wenjin Wu (8555481) (author), Marco Petrillo (64342) (author), Albert S. B. Edge (9450119) (author)
منشور في: 2025
الموضوعات:
Biophysics
Biochemistry
Microbiology
Cell Biology
Genetics
Molecular Biology
Immunology
Developmental Biology
Hematology
Biological Sciences not elsewhere classified
late embryogenesis results
extra hair cells
cognate e3 ligase
cochlear hair cells
bhlh transcription factor
3 ’ enhancer
regulate atoh1 transcription
atoh1 protein increases
atoh1 protein despite
positive feedback loop
helix transcription factor
div >< p
atoh1 </
sox2 interacts
sox2 </
proneural basic
powerful initiator
overexpression decreased
new mechanism
knockout early
inhibition represents
huwe1 loci
huwe1 </
direct binding
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