Chemical Composition and Backbone Modifications Define Deformability of Nucleic Acid Nanoparticles

Nucleic acid nanoparticles (NANPs), composed of short oligonucleotides assembled into specific architectures, are emerging as a programmable platform for the regulated drug delivery of various therapeutic agents. Here, we use a nanopore “clamp” to investigate the mechanical properties of six-strande...

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Bibliografiset tiedot
Päätekijä:	Laxmi Pandey (18762706) (author)
Muut tekijät:	Martin Panigaj (345008) (author), Yasmine Radwan (15359476) (author), Hemani Chhabra (9616507) (author), Yu Chen (29959) (author), Aleksei Aksimentiev (1234707) (author), Kirill A. Afonin (1371708) (author), Meni Wanunu (836580) (author)
Julkaistu:	2025
Aiheet:	Biophysics Biochemistry Medicine Cell Biology Genetics Molecular Biology Biotechnology Developmental Biology Cancer Mental Health Infectious Diseases Computational Biology Chemical Sciences not elsewhere classified Physical Sciences not elsewhere classified various therapeutic agents short oligonucleotides assembled regulated drug delivery atom md simulations nanps ), composed dna cubes deform analogous rna cubes rna cubes dna cubes stranded rna state nanopores specific architectures rna content reveal differences pure dna programmable platform overall shape nanocube stiffness molecular level modified rna mechanical properties mechanical flexibility mechanical deformability hybrid rna hybrid dna electrophoretically forced comparable voltage chemical composition cannot squeeze based nanps additive effect 10 nm
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Chemical Composition and Backbone Modifications Define Deformability of Nucleic Acid Nanoparticles

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