Gene fusions detected by qRT-PCR and tNGS.

<p>qRT-PCR identified a total of 102 gene fusions on RNA-level, whereas tNGS detected 98 out of the 102 gene fusions on DNA-level, leaving 4 gene fusions undetected at this level. Moreover, tNGS on DNA-level revealed two additional gene fusions not detected by qRT-PCR.</p>

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Bibliographic Details
Main Author:	Bin Chen (63682) (author)
Other Authors:	Zhihui Gao (5195756) (author), Long Chen (315739) (author), Hong Zhang (25820) (author), Yani Lin (12629663) (author), Jing Li (10611) (author)
Published:	2025
Subjects:	Biochemistry Medicine Microbiology Cell Biology Genetics Molecular Biology Cancer Hematology Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified us diagnostics lab positive percent agreement necessitating additional methods false positive findings common breakpoint regions gene fusion alterations employing tngs methods two gene fusions tngs method identified detect genetic mutations confirm genomic rearrangements 357 adults diagnosed pcr method detected leukemia gene fusions 102 gene fusions gene fusions pcr method gene rearrangements used simultaneously targeted next study confirms rna samples precise analysis myc </ mllt3 </ kmt2a </ independently developed igh </ gone undetected generation sequencing ell </ commonly used also identify accurately identify 95 introns 26 genes
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Gene fusions detected by qRT-PCR and tNGS.

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