EF-24 induces significant transcriptional changes in K-562 cells.

<p>(A) Heatmap of the top 100 genes differentially regulated in EF-24–treated cells versus the untreated control (red = induced; black = reduced). Cutoff fold change 5 ≥ p-value <0.01. (B) Top 25 molecules changed in EF-24–treated cells versus untreated control K-562 cells. (C) Box plots sh...

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Bibliographic Details
Main Author:	Ajeet P. Singh (22298432) (author)
Other Authors:	Noah Wax (8831360) (author), James Duncan (8309970) (author), Ana S. Fernandes (6021773) (author), Jonathan L. Jacobs (22298435) (author)
Published:	2025
Subjects:	Biochemistry Medicine Cell Biology Genetics Molecular Biology Pharmacology Cancer Hematology Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified polyphenolic compound derived curcuma longa </ regulate cell survival cell lines hl cell line models cell line k wide functional impacts improved pharmacological properties associating druggable genes chronic myeloid leukemia acute myeloid leukemia reduced cell viability various signaling pathways testable model system div >< p four cell lines cell viability signaling pathways wide range therapeutic properties genes atf3 leukemia subtypes leukemia research leukemia cells used whole untreated controls transcriptome sequencing transcriptional response significantly decreased results enabled potential mechanisms poor bioavailability multifaceted impact molecular underpinnings limited due l ., immune responses identify genome genomic discovery gene networks consistently upregulated consistently activated clinical efficacy antitumor efficacy
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EF-24 induces significant transcriptional changes in K-562 cells.

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