Human dorsolateral prefrontal cortex (DLPFC) spatial transcriptomics analysis, 10X Visium data.

A: Cortical Layer Identification — Ground truth cortical layer annotations (left) compared to spatial domains identified by RASP, PCA, and other competing methods, demonstrating spatial domain delineation accuracy. B: Runtime Comparison — Computational...

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Ian K. Gingerich (22822222) (author)
مؤلفون آخرون:	Brittany A. Goods (4419490) (author), H. Robert Frost (10994582) (author)
منشور في:	2025
الموضوعات:	Cancer Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Information Systems not elsewhere classified support flexible integration stage pca framework mechanisms underlying development computationally efficient method achieving substantial improvements >&# 946 ;</ provides critical insights different parameter settings rasp empowers users rasp delivers comparable understanding tissue architecture domain detection method div >< p randomized spatial pca configurable spatial smoothing domain detection smoothing parameter randomized two critical capability smoothing parameters spatial transcriptomics spatial regions spatial organization rasp pcs rasp ): rasp ), transcriptomic covariates throughput fashion superior accuracy resource requirements reduces runtime reconstruct de noise suppression mouse tissues magnitude faster intricate relationship gene expression existing techniques enabling researchers enabling rapid disease progression dimensionality reduction computational speed cellular environments cell types broad range biological function also makes 10x xenium 10x visium
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Human dorsolateral prefrontal cortex (DLPFC) spatial transcriptomics analysis, 10X Visium data.

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