GP41+ SPION+ MNGC in the CNS of an animal with AIDS and SIVE.

(A) SPION (Green (early) and Blue (late)) localize to a gp41+ (red) MNGC in the cerebellum. (B) SPION (Green (early) and Blue (late)) localize to a SIV-RNA+ (red) macrophages within SIVE lesions in the CNS cortical tissue. Nuclei (grey) are stai...

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Bibliographic Details
Main Author:	Zoey K. Wallis (17725175) (author)
Other Authors:	Cecily C. Midkiff (11083425) (author), Miaoyun Zhao (18996267) (author), Patrick Autissier (93068) (author), Soon Ok Kim (22756434) (author), Addison Q. Amadeck (22756437) (author), Yiwei Wang (403386) (author), Maia Jakubowski (22756440) (author), Tricia H. Burdo (9592101) (author), Andrew D. Miller (328799) (author), Qingsheng Li (515132) (author), Xavier Alvarez (33185) (author), Robert V. Blair (11722847) (author), Kenneth C. Williams (11527354) (author)
Published:	2025
Subjects:	Medicine Microbiology Neuroscience Immunology Infectious Diseases Plant Biology Virology Environmental Sciences not elsewhere classified sup >+</ sup simian immunodeficiency virus peripheral sites including myeloid cell egress human immunodeficiency virus dorsal root ganglia central nervous system track macrophage turnover observed higher numbers labeled macrophages within div >< p cns viral reservoirs art reduces trafficking cns </ p perivascular macrophage reservoir following art interruption meningeal macrophages persisted meningeal macrophages increased choroid plexus macrophages art eliminated siv scattered viral rna choroid plexus macrophage traffic art interruption meningeal macrophages trafficking diminished scattered siv low numbers treatment interruption perivascular macrophages macrophages trafficked infected macrophages viral infection art treatment art decreased preferentially taken lesser extent infected macaques findings support enabling us c .) assess establishment antiretroviral therapy administered intracisternal 30 days
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GP41<sup>+</sup> SPION<sup>+</sup> MNGC in the CNS of an animal with AIDS and SIVE.

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