Multifunctional Hydrogel Flakes: An Innovative Approach to Localized Delivery of Temozolomide

The multifunctional systems presented here introduce an innovative and deeply thought-out approach to the more effective and safer use of temozolomide (TMZ) in treating glioma. The developed hydrogel-based flakes were designed to address the issues of local GBL therapy, bacterial neuroinfections, an...

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מחבר ראשי:	Aleksandra Krajcer (22215842) (author)
מחברים אחרים:	Alicja Hinz (11558002) (author), Monika Bzowska (112353) (author), Adrian Grzonka (22215845) (author), Sylwia Stankiewicz (20637723) (author), Kamil Kornaus (22215848) (author), Bartosz Trzewik (9936095) (author), Kinga Wójcik (5123165) (author), Ewelina Grzywna (22215851) (author), Joanna Lewandowska-Łańcucka (5123171) (author)
יצא לאור:	2025
נושאים:	Biochemistry Medicine Pharmacology Biotechnology Cancer Space Science Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified surrounding brain parenchyma possesses antimicrobial properties physicochemical feature assessments local gbl therapy bleeding control needed presented multifunctional long ex vivo </ sustained tmz release multifunctional hydrogel flakes multifunctional systems presented presented methods developed hydrogel based flakes vitro </ tumor resection treating glioma surgical resection surgery site simultaneously displaying safer use results describe results confirmed recurrence ). polymeric capsules localized delivery like forms hyaluronic acid hemostatic property hemostatic potential drug dose developed systems deeply thought dedicated solutions common site calcium cations biological evaluation bacterial neuroinfections also incorporated
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Multifunctional Hydrogel Flakes: An Innovative Approach to Localized Delivery of Temozolomide

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