pAb<sub>2AT-L</sub> protects i<sup>3</sup>Neurons from Aβ<sub>42</sub>-mediated toxicity as measured by ATP production and LDH release.

pAb<sub>2AT-L</sub> protects i<sup>3</sup>Neurons from Aβ<sub>42</sub>-mediated toxicity as measured by ATP production and LDH release.

<p>(A) ATP production by i<sup>3</sup>Neurons in the presence of Aβ<sub>42</sub> with varying concentrations of pAb<sub>2AT-L</sub>, measured by the Promega CellTiter-Glo 2.0 assay (n = 3 technical replicates). (B) LDH release by i<sup>3</sup>Neu...

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Auteur principal:	Sarah M. Ruttenberg (22208828) (author)
Autres auteurs:	Rakia Dhaoui (9389669) (author), Adam G. Kreutzer (1673791) (author), James S. Nowick (1272555) (author)
Publié:	2025
Sujets:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Neuroscience Biotechnology Evolutionary Biology Developmental Biology Cancer Mental Health Infectious Diseases Virology Computational Biology Chemical Sciences not elsewhere classified tem studies indicate protects human ipsc oligomer mimic composed identifying structural features xlink "> 2at three disulfide bonds simply sequester monomeric laboratory recently reported exhibit neuroprotective effects div >< p ad brain tissue &# 946 ;. stoichiometric ratios suggests l </ sub &# 946 stoichiometric ratios molar ratios triangular fashion structurally defined moderately selective many aspects important tools diffuse peripheries derived neurons current study covalently stabilized binds toxic aβ peptide alzheimer ’
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