Insulin secretion assay using MIN6-6.

Insulin secretion assay using MIN6-6.

<p><b>(A)</b> Insulin secretion assay in MIN6-6 cells under different stimulation conditions. Cells were treated with glucose (25 mM), GLP-1 (1 µM), or both. (Glucose: ****<i>P</i> < 0.0001; GLP-1: **<i>P</i> < 0.0052; Glucose and GLP-1: ****<i>P...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: Ha Neul Lee (7360352) (author)
مؤلفون آخرون: Julia C. Hardy (21781692) (author), Emily H. Pool (14883318) (author), Jin-Fan Zhang (21781695) (author), Su Hyun Kim (828853) (author), William F. Buhl (21781698) (author), Jessica G.H. Bruystens (21781701) (author), Sohum Mehta (2000764) (author), Susan S. Taylor (44167) (author), Jin Zhang (53297) (author)
منشور في: 2025
الموضوعات:
Biochemistry
Microbiology
Cell Biology
Genetics
Molecular Biology
Physiology
Developmental Biology
Cancer
Virology
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
ubiquitous second messenger
selective molecular tool
reveal key roles
prevent uncontrolled proliferation
min6 β cells
mediated gene expression
facilitate spatial compartmentalization
dependent protein kinase
cyclic adenosine monophosphate
control insulin secretion
based riα knockout
exhibits defective camp
camp oscillation frequency
div >< p
2 +</ sup
studying riα llps
pka ), riα
camp ),
riα mutant
riα llps
riα condensates
regulatory subunit
regulate creb
previously showed
pka type
phase separation
largely unknown
induced llps
high specificity
functional impact
data establish
combining crispr
cellular functions
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