Distinct effects of CVB3-2Awt and CVB3-2Amut on cell morphology and death.

(A) HeLa-R19 cells were infected with 3 CDcs-2Awt and 3 CDcs-2Amut at an MOI of 50, fixed at 6, 8, 10, 12 and 16 hpi and, and analyzed by IF analysis. Nuclei were stained with DAPI, dsRNA was detected as marker for infection, and β-tubulin was u...

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Bibliographic Details
Main Author:	Jelle G. Schipper (16866034) (author)
Other Authors:	Chiara Aloise (8374950) (author), Sereina O. Sutter (13029037) (author), Marleen Zwaagstra (9611632) (author), Arno L.W. van Vliet (22139247) (author), Rana Abdelnabi (2145439) (author), Bob Ignacio (6836786) (author), Kimberly M. Bonger (1856443) (author), Dagmar Roelofs (22139250) (author), Judith M.A. van den Brand (22139253) (author), Richard W. Wubbolts (3797863) (author), Lucas J.M. Bruurs (22139256) (author), Hendrik Jan Thibaut (550169) (author), Johan Neyts (55640) (author), Marvin E. Tanenbaum (17093939) (author), Frank J. M. van Kuppeveld (7252571) (author)
Published:	2025
Subjects:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Ecology Immunology Mental Health Infectious Diseases Virology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified subverting antiviral responses induced restriction factors host mrna translation enteroviruses dramatically remodel disturbing nucleocytoplasmic transport incoming viral rna surrogate infection systems catalytically inactivate 2a viral 2a protease pro </ sup div >< p viral proteins vitro </ efficient infection inactive 2a virus context t2a sequence studied mostly severely attenuated p2 junction overcoming ifn multifaceted role initial round ifn response favorable environment ectopic overexpression critical role coxsackievirus b3 cellular infrastructure cell lines allowing us advanced single
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Distinct effects of CVB3-2Awt and CVB3-2Amut on cell morphology and death.

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