A835D reduces thermostability of the SHC014-CoV spike.

(a) scVSV-SHC014-CoV S particles were incubated at various temperatures for 1 h and used to infect DBT-9 cells overexpressing RaACE2. (average±SD, n = 4–6 from 2–3 independent experiments). Infectivity levels were normalized to the infectivity percentag...

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المؤلف الرئيسي:	Alexandra L. Tse (20235212) (author)
مؤلفون آخرون:	Cory M. Acreman (20235215) (author), Inna Ricardo-Lax (4543948) (author), Jacob Berrigan (11052951) (author), Gorka Lasso (215085) (author), Toheeb Balogun (20235218) (author), Fiona L. Kearns (11841216) (author), Lorenzo Casalino (2850134) (author), Georgia L. McClain (20235221) (author), Amartya Mudry Chandran (20235224) (author), Charlotte Lemeunier (20235227) (author), Rommie E. Amaro (82566) (author), Charles M. Rice (9110743) (author), Rohit K. Jangra (6639905) (author), Jason S. McLellan (8816639) (author), Kartik Chandran (134142) (author), Emily Happy Miller (10652108) (author)
منشور في:	2024
الموضوعات:	Microbiology Cell Biology Neuroscience Evolutionary Biology Immunology Cancer Mental Health Infectious Diseases Virology Environmental Sciences not elsewhere classified zoonotic risks posed xlink "> understanding s2 fusion peptide cell entry mechanisms like bat cov divergent bat covs enhanced receptor binding cell entry binding domain bat covs bat coronaviruses viral entry cellular receptor enhanced spike virus bearing terminal domain successful recovery spike receptor serial passage second substitution proximal region pandemic preparedness offs inherent novel substitution fppr substitution fppr ). fitness trade coronavirus contexts bearing spikes
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A835D reduces thermostability of the SHC014-CoV spike.

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