A835D reduces thermostability of the SHC014-CoV spike.

A835D reduces thermostability of the SHC014-CoV spike.

<p><b>(a)</b> scVSV-SHC014-CoV S particles were incubated at various temperatures for 1 h and used to infect DBT-9 cells overexpressing <i>Ra</i>ACE2. (average±SD, n = 4–6 from 2–3 independent experiments). Infectivity levels were normalized to the infectivity percentag...

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Main Author: Alexandra L. Tse (20235212) (author)
Other Authors: Cory M. Acreman (20235215) (author), Inna Ricardo-Lax (4543948) (author), Jacob Berrigan (11052951) (author), Gorka Lasso (215085) (author), Toheeb Balogun (20235218) (author), Fiona L. Kearns (11841216) (author), Lorenzo Casalino (2850134) (author), Georgia L. McClain (20235221) (author), Amartya Mudry Chandran (20235224) (author), Charlotte Lemeunier (20235227) (author), Rommie E. Amaro (82566) (author), Charles M. Rice (9110743) (author), Rohit K. Jangra (6639905) (author), Jason S. McLellan (8816639) (author), Kartik Chandran (134142) (author), Emily Happy Miller (10652108) (author)
Published: 2024
Subjects:
Microbiology
Cell Biology
Neuroscience
Evolutionary Biology
Immunology
Cancer
Mental Health
Infectious Diseases
Virology
Environmental Sciences not elsewhere classified
zoonotic risks posed
xlink "> understanding
s2 fusion peptide
cell entry mechanisms
like bat cov
divergent bat covs
enhanced receptor binding
cell entry
binding domain
bat covs
bat coronaviruses
viral entry
cellular receptor
enhanced spike
virus bearing
terminal domain
successful recovery
spike receptor
serial passage
second substitution
proximal region
pandemic preparedness
offs inherent
novel substitution
fppr substitution
fppr ).
fitness trade
coronavirus contexts
bearing spikes
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