Damage to vmPFC and ventral striatum increases temporal impulsivity, including both mPFC lesion participants and lesion controls.

<p><b>(a)</b> Permutation-based, whole-brain, nonparametric voxel-based lesion-symptom mapping (VLSM) showed that the area 25 in the vmPFC as well as ventral striatum where damage was correlated with heightened temporal impulsivity (permutation-based threshold free cluster enhancem...

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Bibliographic Details
Main Author:	Zhilin Su (11080197) (author)
Other Authors:	Mona M. Garvert (7061030) (author), Lei Zhang (38117) (author), Todd A. Vogel (21192658) (author), Jo Cutler (10171152) (author), Masud Husain (300883) (author), Sanjay G. Manohar (18389774) (author), Patricia L. Lockwood (10664004) (author)
Published:	2025
Subjects:	Medicine Neuroscience Sociology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified unusually large sample medial prefrontal cortex free cluster enhancement computational parameters showed gradient supporting social distinct ventral portions 33 ), individuals temporal discounting task social influence compared increased overall susceptibility div >< p estimate baseline discounting baseline discounting preferences healthy controls (< lesions elsewhere (< temporal discounting social influence healthy controls ventral striatum social decision lesions elsewhere 17 ), mpfc (< temporally impulsive symptom mapping specific functions rare participants participants completed p </ nonsocial cognition neuroimaging studies n </ immediate rewards heightened susceptibility causally implicated based threshold based lesion attributed specifically areas 13 area 9 121 ). 05 ). 025 ).
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Damage to vmPFC and ventral striatum increases temporal impulsivity, including both mPFC lesion participants and lesion controls.

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