SHAP values for H3K4me3, co-occupying PRC1 (RING1B) and PRC2 (SUZ12) components and their catalytic marks across multiple time points following RING1B degradation.

SHAP values for H3K4me3, co-occupying PRC1 (RING1B) and PRC2 (SUZ12) components and their catalytic marks across multiple time points following RING1B degradation.

<p>(A) Absolute mean DeepSHAP values computed for direct targets (RING1B degron 2h) and random genes at promoter and gene body contexts. Random subsampling is used to calculate intra-category variability and the error bars indicate the standard deviation of one-half. (B) Heatmap of absolute me...

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Bibliographic Details
Main Author: Kashyap Chhatbar (9515350) (author)
Other Authors: Adrian Bird (84938) (author), Guido Sanguinetti (343362) (author)
Published: 2025
Subjects:
Biochemistry
Microbiology
Cell Biology
Genetics
Molecular Biology
Marine Biology
Plant Biology
Biological Sciences not elsewhere classified
Information Systems not elsewhere classified
suggesting crosstalk mediated
shapley additive explanations
predict rna pol
mechanistically remains challenging
infer functional relevance
dependent regulatory networks
integrating predictive modelling
insights using data
based perturbation experiments
associated protein profiles
unravel complex context
unperturbed data
perturbation even
modelling transcription
associated proteins
restrictor complex
integrator complex
compass complex
unperturbed conditions
transcriptional regulation
transcriptional changes
influencing transcription
ii occupancy
genes ranked
gene bodies
findings highlight
experimental validation
cooperative roles
analysis reveals
also captures
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