Simulation Analysis to Investigate Palbociclib Dose Response Discrepancy.

<p>A. Simulated cell growth curves under control conditions for multiple replicates. The dark black line is the median which was used to estimate doubling time, when the initial cell number (100) doubled (200). B. The fractional progression through the cell cycle (see Methods) was estimated fo...

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Bibliographic Details
Main Author:	Arnab Mutsuddy (22146227) (author)
Other Authors:	Jonah R. Huggins (13235400) (author), Aurore K. Amrit (22146230) (author), Atalanta Manuela Harley-Gasaway (22146233) (author), Cemal Erdem (11054081) (author), Evan T. Jones (22146236) (author), Olivia G. Laurine (22146239) (author), Jon C. Calhoun (22146242) (author), Marc R. Birtwistle (10825523) (author)
Published:	2025
Subjects:	Biophysics Cell Biology Genetics Molecular Biology Pharmacology Biotechnology Cancer Hematology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified Information Systems not elsewhere classified tracks simulated division strong growth inhibition slowly dividing cells mother cells prior measure cumulative division four targeted anti erk pathway activity better understanding determinants receptor inhibitor response egfr inhibitor ). 3k inhibitor ), mechanistic computational models xlink "> data cell viability assays cell cycle may simulations show subpopulations rapidly dividing phenotype drug treatment impinging data inconsistencies suggest previously developed model mek inhibitor suggest causes mechanistic modeling experimental data data comparison cell proliferation cell lineages 6 inhibitor work lays widely available treated conditions silico </ overall lack often muddled mammalian single lineage tracing induced signaling direct model detailed single death signaling death events critical determinant cellular heterogeneity cellular balance cancer drugs
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Simulation Analysis to Investigate Palbociclib Dose Response Discrepancy.

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