Design, Synthesis, and Biological Activity of Novel Ornithine Decarboxylase (ODC) Inhibitors

Design, Synthesis, and Biological Activity of Novel Ornithine Decarboxylase (ODC) Inhibitors

We here describe the design, synthesis, and biological activity of novel ornithine decarboxylase (ODC) inhibitors that show significantly higher potency <i>in vitro</i> than α-difluoromethylornithine (DFMO), a U.S. Food and Drug Administration (FDA) approved drug. We report two X-ray str...

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Bibliographic Details
Main Author: Chad R. Schultz (4686190) (author)
Other Authors: Bilal Aleiwi (7495334) (author), X. Edward Zhou (8566920) (author), Kelly Suino-Powell (376647) (author), Karsten Melcher (301766) (author), Nuno M. S. Almeida (14323012) (author), Angela K. Wilson (1269099) (author), Edmund L. Ellsworth (2521243) (author), André S. Bachmann (2050090) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Pharmacology
Biotechnology
Immunology
Cancer
Hematology
Chemical Sciences not elsewhere classified
Information Systems not elsewhere classified
novel ornithine decarboxylase
clinically validated target
human odc enzyme
report two x
ray structures reveal
potent odc inhibitors
new odc inhibitors
ray structures
odc inhibitor
odc complexed
endogenous odc
vitro </
superior activity
several indications
pyridoxal phosphate
polyamine levels
physical properties
molecular dynamics
experimental models
enzymatic testing
drug administration
covalent adducts
computational docking
clinical use
cellular activity
biological activity
approved drug
active site
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